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J Neurophysiol 81: 967-976, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 81 No. 3 March 1999, pp. 967-976
Copyright ©1999 by the American Physiological Society

Dopamine Modulation of Membrane and Synaptic Properties of Interneurons in Rat Cerebral Cortex

Fu-Ming Zhou and John J. Hablitz

Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294

Zhou, Fu-Ming and John J. Hablitz. Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex. Dopamine (DA) is an endogenous neuromodulator in the mammalian brain. However, it is still controversial how DA modulates excitability and input-output relations in cortical neurons. It was suggested that DA innervation of dendritic spines regulates glutamatergic inputs to pyramidal neurons, but no experiments were done to test this idea. By recording individual neurons under direct visualization we found that DA enhances inhibitory neuron excitability but decreases pyramidal cell excitability, through depolarization and hyperpolarization, respectively. Accordingly, DA also increased the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs). In the presence of TTX, DA did not affect the frequency, amplitude, or kinetics of miniature IPSCs and excitatory postsynaptic currents in inhibitory interneurons or pyramidal cells. Our results suggest that DA can directly excite cortical interneurons, but there is no detectable DA gate to regulate spontaneous GABA and glutamate release or the properties of postsynaptic GABA and glutamate receptors in neocortical neurons.




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