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The Journal of Neurophysiology Vol. 81 No. 4 April 1999, pp. 1478-1485
Copyright ©1999 by the American Physiological Society
Department of Physiological Science, University of California, Los Angeles, California 90095-1568
del Negro, Christopher A.,
Chie-Fang Hsiao, and
Scott H. Chandler.
Outward currents influencing bursting dynamics in guinea pig trigeminal
motoneurons. To initiate and maintain bursts (and plateau
potentials) in the presence of serotonin, guinea pig trigeminal motoneurons utilize L-type Ca2+ and persistent
Na+ inward currents. However, the intrinsic currents that
contribute to burst termination and determine the duration of the
interburst interval are unknown. Therefore we investigated the roles of
outward currents, whose slow activation is coupled to cytosolic cation (Ca2+ and Na+) accumulation. First we examined
a Ca2+-dependent K+ current
(IK-Ca) with apamin and
Ba2+-substituted, low-Ca2+ solution. Blockade
of IK-Ca lengthened burst duration and cycle time but did not abolish bursting. Next we studied the
Na+/K+-ATPase pump current
(Ip) with cardiac glycosides. In the presence of
apamin or low-Ca2+/Ba2+ solution, blocking
Ip (with ouabain or strophanthidin) decreased both burst duration and cycle time and ultimately transformed bursting
into tonic spiking. We conclude that IK-Ca and
Ip contribute to burst termination in trigeminal
motoneurons. These currents influence temporal bursting properties such
as burst duration and cycle time and may help determine the phasic
activity of motoneurons during rhythmic oral-motor behaviors.
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