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The Journal of Neurophysiology Vol. 81 No. 4 April 1999, pp. 1927-1938
Copyright ©1999 by the American Physiological Society
Department of Physiology, Tohoku University School of Medicine, Sendai 980-8575, Japan
Kurata, Kiyoshi and
Eiji Hoshi.
Reacquisition deficits in prism adaptation after muscimol
microinjection into the ventral premotor cortex of monkeys. A
small amount of muscimol (1 µl; concentration, 5 µg/µl) was
injected into the ventral and dorsal premotor cortex areas (PMv and
PMd, respectively) of monkeys, which then were required to perform a
visually guided reaching task. For the task, the monkeys were required
to reach for a target soon after it was presented on a screen. While
performing the task, the monkeys' eyes were covered with left 10°,
right 10°, or no wedge prisms, for a block of 50-100 trials. Without
the prisms, the monkeys reached the targets accurately. When the prisms
were placed, the monkeys initially misreached the targets because the
prisms displaced the visual field. Before the muscimol injection, the
monkeys adapted to the prisms in 10-20 trials, judging from the
horizontal distance between the target location and the point where the
monkey touched the screen. After muscimol injection into the PMv, the
monkeys lost the ability to readapt and touched the screen closer to
the location of the targets as seen through the prisms. This deficit
was observed at selective target locations, only when the targets were
shifted contralaterally to the injected hemisphere. When muscimol was injected into the PMd, no such deficits were observed. There were no
changes in the reaction and movement times induced by muscimol injections in either area. The results suggest that the PMv plays an
important role in motor learning, specifically in recalibrating visual
and motor coordinates.
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