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J Neurophysiol 81: 1970-1973, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 81 No. 4 April 1999, pp. 1970-1973
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

Thalamic Relay Site for Cold Perception in Humans

Karen D. Davis,1,3 Andres M. Lozano,1,3 Marosh Manduch,2 Ronald R. Tasker,1,3 Zelma H. T. Kiss,1 and Jonathan O. Dostrovsky2,3

 1Department of Surgery and  2Department of Physiology, University of Toronto; and  3Playfair Neuroscience Unit/The Toronto Hospital Research Institute, The Toronto Hospital, Toronto, Ontario M5S 1A8, Canada

Davis, Karen D., Andres M. Lozano, Marosh Manduch, Ronald R. Tasker, Zelma H. T. Kiss, and Jonathan O. Dostrovsky.   Thalamic relay site for cold perception in humans. The neural pathways subserving the sensation of temperature are virtually unknown. However, recent findings in the monkey suggest that the sensation of cold may be mediated by an ascending pathway relaying in the posterior part of the thalamic ventromedial nucleus (VMpo). To test this hypothesis we examined the responses of neurons to thermal stimulation of the skin and determined the perceptual effects of microstimulation in the VMpo region in awake patients undergoing functional stereotactic surgery. In 16 patients, microstimulation in the VMpo region evoked cold sensations in a circumscribed body part. Furthermore, at some of these sites thalamic neurons were found that responded to innocuous cooling of the skin area corresponding to the stimulation-evoked cold sensations. These data provide the first direct demonstration of a pathway mediating cold sensation and its location in the human thalamus.




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