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The Journal of Neurophysiology Vol. 81 No. 4 April 1999, pp. 1974-1977
Copyright ©1999 by the American Physiological Society
RAPID COMMUNICATION
CNS Research, Wyeth-Ayerst Research, Princeton, New Jersey 08543
Dilks, Daniel,
Huai-Ping Ling,
Mark Cockett,
Patricia Sokol, and
Randy Numann.
Cloning and expression of the human Kv4.3 potassium channel. We
report on the cloning and expression of hKv4.3, a fast inactivating, transient, A-type potassium channel found in both heart and brain that
is 91% homologous to the rat Kv4.3 channel. Two isoforms of hKv4.3
were cloned. One is full length (hKv4.3 long), and the other has a 19 amino acid deletion (hKv4.3 short). RT-PCR shows that the brain
contains both forms of the channel RNA, whereas the heart predominantly
has the longer version. Both versions of the channel were expressed in
Xenopus oocytes, and both contain a significant window or
noninactivating current seen near potentials of 
30 to 40 mV. The
inactivation curve for hKv4.3 short is shifted 10 mV positive relative
to hKv4.3 long. This causes the peak window current for the short
version to occur near 30 mV and the peak for the longer version to be
at 40 mV. There was little difference in the recovery from
inactivation or in the kinetics of inactivation between the two
isoforms of the channel.
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