| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 81 No. 5 May 1999, pp. 2398-2405
Copyright ©1999 by the American Physiological Society
Department of Neurobiology and Behaviour, State University of New York at Stony Brook, Stony Brook, New York 11794-5230
Seebach, Bradley S.,
Viktor Arvanov, and
Lorne M. Mendell.
Effects of BDNF and NT-3 on Development of Ia/Motoneuron
Functional Connectivity in Neonatal Rats. J. Neurophysiol. 81: 2398-2405, 1999.
Effects of BDNF and NT-3 on development of Ia/motoneuron functional
connectivity in neonatal rats. The effects of neurotrophin administration and neurotrophin removal via administration of tyrosine
kinase (trk) immunoadhesins (trk receptor extracellular domains
fused with IgG heavy chain) on the development of segmental reflexes
were studied in neonatal rats. Brain derived neurotrophic factor
(BDNF), neurotrophin-3 (NT-3), trkB-IgG, and trkC-IgG were delivered via subcutaneous injection on days 0, 2, 4, and 6 of postnatal life. Electrophysiological analysis of EPSPs recorded intracellularly in L5 motoneurons in response to
stimulation of dorsal root L5 was carried out on postnatal
day 8 in the in vitro hemisected spinal cord. Treatment with BDNF
resulted in smaller monosynaptic EPSPs with longer latency than those
in controls. EPSP amplitude became significantly larger when BDNF was
sequestered with trkB-IgG, suggesting that BDNF has a tonic action on
the development of this synapse in neonates. Treatment with NT-3
resulted in larger EPSPs, but the decrease noted after administration
of trkC-IgG was not significant. Neurotrophins had little effect on the
response to high-frequency dorsal root stimulation or on motoneuron
properties. Polysynaptic components were exaggerated in BDNF-treated
rats and reduced after NT-3 compared with controls. As in control
neonates the largest monosynaptic EPSPs in NT-3 and trkB-IgG-treated
preparations were observed in motoneurons with relatively large values
of rheobase, probably those that are growing the most rapidly. We
conclude that supplementary NT-3 and BDNF administered to neonates can
influence developing Ia/motoneuron synapses in the spinal cord but with
opposite net effects.
This article has been cited by other articles:
|
|
 |
|
  S. Tazerart, J.-C. Viemari, P. Darbon, L. Vinay, and F. Brocard Contribution of Persistent Sodium Current to Locomotor Pattern Generation in Neonatal Rats J Neurophysiol, August 1, 2007; 98(2): 613 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Ramer, L. T. McPhail, J. F. Borisoff, L. J. J. Soril, T. K. Y. Kaan, J. H. T. Lee, J. W. T. Saunders, L. P. R. Hwi, and M. S. Ramer Endogenous TrkB Ligands Suppress Functional Mechanosensory Plasticity in the Deafferented Spinal Cord J. Neurosci., May 23, 2007; 27(21): 5812 - 5822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, L. Y. Li, M. D. Taylor, D. E. Wright, and E. Frank Prenatal Exposure to Elevated NT3 Disrupts Synaptic Selectivity in the Spinal Cord J. Neurosci., April 4, 2007; 27(14): 3686 - 3694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Arvanian, W. J. Bowers, J. C. Petruska, V. Motin, H. Manuzon, W. C. Narrow, H. J. Federoff, and L. M. Mendell Viral Delivery of NR2D Subunits Reduces Mg2+ Block of NMDA Receptor and Restores NT-3-Induced Potentiation of AMPA-Kainate Responses in Maturing Rat Motoneurons J Neurophysiol, October 1, 2004; 92(4): 2394 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mousavi, D. J. Parry, and B. J. Jasmin BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury Am J Physiol Cell Physiol, July 1, 2004; 287(1): C22 - C29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Arvanian, P. J. Horner, F. H. Gage, and L. M. Mendell Chronic Neurotrophin-3 Strengthens Synaptic Connections to Motoneurons in the Neonatal Rat J. Neurosci., September 24, 2003; 23(25): 8706 - 8712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Carrasco and A. W. English Neurotrophin 4/5 is required for the normal development of the slow muscle fiber phenotype in the rat soleus J. Exp. Biol., July 1, 2003; 206(13): 2191 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-H. Chen, W. G. Tourtellotte, and E. Frank Muscle Spindle-Derived Neurotrophin 3 Regulates Synaptic Connectivity between Muscle Sensory and Motor Neurons J. Neurosci., May 1, 2002; 22(9): 3512 - 3519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Arvanian and L. M. Mendell Removal of NMDA Receptor Mg2+ Block Extends the Action of NT-3 on Synaptic Transmission in Neonatal Rat Motoneurons J Neurophysiol, July 1, 2001; 86(1): 123 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Arvanov, B. S. Seebach, and L. M. Mendell NT-3 Evokes an LTP-Like Facilitation of AMPA/Kainate Receptor-Mediated Synaptic Transmission in the Neonatal Rat Spinal Cord J Neurophysiol, August 1, 2000; 84(2): 752 - 758. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
