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The Journal of Neurophysiology Vol. 81 No. 6 June 1999, pp. 2597-2611
Copyright ©1999 by the American Physiological Society
Department of Physiology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan
Izawa, Y.,
Y. Sugiuchi, and
Y. Shinoda.
Neural Organization From the Superior Colliculus to Motoneurons
in the Horizontal Oculomotor System of the Cat. J. Neurophysiol. 81: 2597-2611, 1999.
Neural organization from the superior colliculus to motoneurons in the
horizontal oculomotor system of the cat. The neural organization of the superior colliculus (SC) projection to horizontal ocular motoneurons was analyzed in anesthetized cats using
intracellular recording and transneuronal labeling. Intracellular
responses to SC stimulation were analyzed in lateral rectus (LR) and
medial rectus (MR) motoneurons and internuclear neurons in the abducens nucleus (AINs). LR motoneurons and AINs received excitation from the
contralateral SC and inhibition from the ipsilateral SC. The shortest
excitation (0.9-1.9 ms) and inhibition (1.4-2.4 ms) were mainly
disynaptic from the SC and were followed by tri- and polysynaptic responses evoked with increasing stimuli or intensity. All MR motoneurons received excitation from the ipsilateral SC, whereas none
of them received any short-latency inhibition from the contralateral SC, but some received excitation. The latency of the ipsilateral excitation in MR motoneurons (1.7-2.8 ms) suggested that this excitation was trisynaptic via contralateral AINs, because conditioning SC stimulation spatially facilitated trisynaptic excitation from the
ipsilateral vestibular nerve. To locate interneurons mediating the
disynaptic SC inputs to LR motoneurons, last-order premotor neurons
were labeled transneuronally after injecting wheat germ agglutinin-conjugated horseradish peroxidase into the abducens nerve,
and tectoreticular axon terminals were labeled after injecting dextran-biotin into the ipsilateral or contralateral SC in the same
preparations. Transneuronally labeled neurons were mainly distributed
ipsilaterally in the paramedian pontine reticular formation (PPRF)
rostral to retrogradely labeled LR motoneurons and the vestibular
nuclei, and contralaterally in the paramedian pontomedullary reticular
formation (PPMRF) caudomedial to the abducens nucleus and the
vestibular nuclei. Among the last-order premotor neuron areas,
orthogradely labeled tectoreticular axon terminals were observed only
in the PPRF and the PPMRF contralateral to the injected SC and seemed
to make direct contacts with many of the labeled last-order premotor
neurons in the PPRF and the PPMRF. These morphological results
confirmed that the main excitatory and inhibitory connections from the
SC to LR motoneurons are disynaptic and that the PPRF neurons that
receive tectoreticular axon terminals from the contralateral SC
terminate on ipsilateral LR motoneurons, whereas the PPMRF neurons that
receive tectoreticular axon terminals from the contralateral SC
terminate on contralateral LR motoneurons.
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