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The Journal of Neurophysiology Vol. 81 No. 6 June 1999, pp. 2956-2963
Copyright ©1999 by the American Physiological Society
Departments of 1Neurosurgery and 2Radiology, State University of New York Health Science Center, Syracuse, New York 13210
Apkarian, A. Vania,
Aneela Darbar,
Beth R. Krauss,
Patricia A. Gelnar, and
Nikolaus M. Szeverenyi.
Differentiating Cortical Areas Related to Pain Perception From
Stimulus Identification: Temporal Analysis of fMRI Activity. J. Neurophysiol. 81: 2956-2963, 1999.
Differentiating cortical areas related to pain perception from stimulus
identification: temporal analysis of fMRI activity. In
a recent functional magnetic resonance imaging study (fMRI), we
reported the cortical areas activated in a thermal painful task and
compared the extent of overlap between this cortical network and those
activated during a vibrotactile task and a motor task. In the
present study we examine the temporal properties of the cortical
activations for all three tasks and use linear systems identification
techniques to functionally differentiate the cortical regions
identified in the painful thermal task. Cortical activity was examined
in the contralateral middle third of the brain of 10 right-handed
subjects, using echo-planar imaging and a surface coil. In another
eight subjects the temporal properties of the thermal task were
examined psychophysically. The fMRI impulse response function was
estimated from the cortical activations in the vibrotactile and motor
tasks and shown to correspond to earlier reports. Given the fMRI
impulse response function and the time courses for the thermal stimulus
and the associated pain ratings, predictor functions were generated.
The correlation between these predictor functions and cortical
activations in the painful thermal task indicated a gradual transition
of information processing anteroposteriorly in the parietal cortex.
Within this region, activity in the anterior areas more closely
reflected thermal stimulus parameters, whereas activity more
posteriorly was better related to the temporal properties of pain
perception. Insular cortex at the level of the anterior commissure was
the region best related to the thermal stimulus, and Brodmann's area
5/7 was the region best related to the pain perception. The functional implications of these observations are discussed.
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