JN AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 81: 3087-3091, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ninomiya, Y.
Right arrow Articles by Sugimura, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ninomiya, Y.
Right arrow Articles by Sugimura, T.

The Journal of Neurophysiology Vol. 81 No. 6 June 1999, pp. 3087-3091
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

Sweet Taste Responses of Mouse Chorda Tympani Neurons: Existence of Gurmarin-Sensitive and -Insensitive Receptor Components

Yuzo Ninomiya,1 Toshiaki Imoto,2 and Tadataka Sugimura1

 1Department of Oral Physiology, Asahi University School of Dentistry, Gifu 501-0296; and  2Department of Physiology, Tottori University School of Medicine, Yonago 683-0826, Japan

Ninomiya, Yuzo, Toshiaki Imoto, and Tadataka Sugimura. Sweet Taste Responses of Mouse Chorda Tympani Neurons: Existence of Gurmarin-Sensitive and -Insensitive Receptor Components. J. Neurophysiol. 81: 3087-3091, 1999.Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components. Inhibitory effects of gurmarin (gur) on responses to sucrose and other sweeteners of single fibers of the chorda tympani nerve in C57BL mice were examined. Of 30 single fibers that strongly responded to 0.5 M sucrose but were not or to lesser extent responsive to 0.1 M NaCl, 0.01 M HCl, and 0.02 M quinine HCl (sucrose-best fibers), 16 fibers showed large suppression of responses to sucrose and other sweeteners by lingual treatment with 4.8 µM (~20 µg/ml) gur (suppressed to 4-52% of control: gur-sensitive fibers), whereas the remaining 14 fibers showed no such gur inhibition (77-106% of control: gur-insensitive fibers). In gur-sensitive fibers, responses to sucrose inhibited by gur recovered to ~70% of control responses after rinsing the tongue with 15 mM beta -cyclodextrin and were almost abolished by further treatment with 2% pronase. In gur-insensitive fibers, sucrose responses were not inhibited by gur, but were largely suppressed by pronase. These results suggest existence of two different receptor components for sweeteners with different susceptibilities to gur in mouse taste cells, one gur sensitive and the other gur insensitive. Taste cells possessing each component may be specifically innervated by a particular type of chorda tympani neurons.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Ohkuri, K. Yasumatsu, N. Horio, M. Jyotaki, R. F. Margolskee, and Y. Ninomiya
Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R960 - R971.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Yoshida, N. Shigemura, K. Sanematsu, K. Yasumatsu, S. Ishizuka, and Y. Ninomiya
Taste Responsiveness of Fungiform Taste Cells With Action Potentials
J Neurophysiol, December 1, 2006; 96(6): 3088 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 Behav Cogn Neurosci RevHome page
A. C. Spector and S. P. Travers
The representation of taste quality in the Mammalian nervous system.
Behav Cogn Neurosci Rev, September 1, 2005; 4(3): 143 - 191.
[Abstract] [PDF]

Home page
 Chem SensesHome page
K. Sanematsu, K. Yasumatsu, R. Yoshida, N. Shigemura, and Y. Ninomiya
Mouse Strain Differences in Gurmarin-sensitivity of Sweet Taste Responses Are Not Associated with Polymorphisms of the Sweet Receptor Gene, Tas1r3
Chem Senses, July 1, 2005; 30(6): 491 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
B. R. Heyer, C. C. Taylor-Burds, J. D. Mitzelfelt, and E. R. Delay
Monosodium Glutamate and Sweet Taste: Discrimination between the Tastes of Sweet Stimuli and Glutamate in Rats
Chem Senses, October 1, 2004; 29(8): 721 - 729.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. H. Lemon, S. M. Brasser, and D. V. Smith
Alcohol Activates a Sucrose-Responsive Gustatory Neural Pathway
J Neurophysiol, July 1, 2004; 92(1): 536 - 544.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. H. Lemon, T. Imoto, and D. V. Smith
Differential Gurmarin Suppression of Sweet Taste Responses in Rat Solitary Nucleus Neurons
J Neurophysiol, August 1, 2003; 90(2): 911 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
Y. Murata, K. Nakashima, A. Yamada, N. Shigemura, K. Sasamoto, and Y. Ninomiya
Gurmarin Suppression of Licking Responses to Sweetener-Quinine Mixtures in C57BL Mice
Chem Senses, March 1, 2003; 28(3): 237 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Kawai, K. Sugimoto, K. Nakashima, H. Miura, and Y. Ninomiya
Leptin as a modulator of sweet taste sensitivities in mice
PNAS, September 19, 2000; (2000) 190066697.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Kawai, K. Sugimoto, K. Nakashima, H. Miura, and Y. Ninomiya
Leptin as a modulator of sweet taste sensitivities in mice
PNAS, September 26, 2000; 97(20): 11044 - 11049.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online