| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 81 No. 6 June 1999, pp. 3092-3095
Copyright ©1999 by the American Physiological Society
RAPID COMMUNICATION
1Departments of Ophthalmology and
Physiology,
Bieda, Mark C. and
David R. Copenhagen.
Sodium Action Potentials Are Not Required for Light-Evoked
Release of GABA or Glycine From Retinal Amacrine Cells. J. Neurophysiol. 81: 3092-3095, 1999.
Sodium action potentials are not required for light-evoked release of
GABA or glycine from retinal amacrine cells. Although most CNS
neurons require sodium action potentials (Na-APs) for normal
stimulus-evoked release of classical neurotransmitters, many types of
retinal and other sensory neurons instead use only graded potentials
for neurotransmitter release. The physiological properties and
information processing capacity of Na-AP-producing neurons appear
significantly different from those of graded potential neurons. To
classify amacrine cells in this dichotomy, we investigated whether
Na-APs, which are often observed in these cells, are required for
functional light-evoked release of inhibitory neurotransmitters from
these cells. We recorded light-evoked inhibitory postsynaptic currents
(IPSCs) from retinal ganglion cells, neurons directly postsynaptic to
amacrine cells, and applied TTX to block Na-APs. In control solution,
TTX application always led to partial suppression of the light-evoked
IPSC. To isolate release from glycinergic amacrine cells, we used
either bicuculline, a GABAA receptor antagonist, or
picrotoxin, a GABAA and GABAC receptor
antagonist. TTX application only partially suppressed the glycinergic
IPSC. To isolate release from GABAergic amacrine cells, we used the
glycine receptor blocker strychnine. TTX application only partially
suppressed the light-evoked GABAergic IPSC. Glycinergic and GABAergic
amacrine cells did not obviously differ in the usage of Na-APs for
release. These observations, in conjunction with previous studies of
other retinal neurons, indicate that amacrine cells, taken as a class,
are the only type of retinal neuron that uses both Na-AP-dependent and
-independent modes for light-evoked release of neurotransmitters. These
results also provide evidence for another parallel between the
properties of retinal amacrine cells and olfactory bulb granule cells.
This article has been cited by other articles:
|
|
 |
|
  A. E. Chavez and J. S. Diamond Diverse Mechanisms Underlie Glycinergic Feedback Transmission onto Rod Bipolar Cells in Rat Retina J. Neurosci., July 30, 2008; 28(31): 7919 - 7928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Warrier, S. Borges, D. Dalcino, C. Walters, and M. Wilson Calcium From Internal Stores Triggers GABA Release From Retinal Amacrine Cells J Neurophysiol, December 1, 2005; 94(6): 4196 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Hoffpauir and E. L. Gleason Modulation of Synaptic Function in Retinal Amacrine Cells Integr. Comp. Biol., August 1, 2005; 45(4): 658 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, Y.-P. Ma, S. A Lipton, and Z.-H. Pan Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells J. Physiol., December 15, 2003; 553(3): 895 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Raz, I. Perlman, C. L. Percicot, G. N. Lambrou, and R. Ofri Functional Damage to Inner and Outer Retinal Cells in Experimental Glaucoma Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3675 - 3684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vigh, E. Solessio, C. W. Morgans, and E. M. Lasater Ionic Mechanisms Mediating Oscillatory Membrane Potentials in Wide-Field Retinal Amacrine Cells J Neurophysiol, July 1, 2003; 90(1): 431 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Shields and P. D. Lukasiewicz Spike-Dependent GABA Inputs to Bipolar Cell Axon Terminals Contribute to Lateral Inhibition of Retinal Ganglion Cells J Neurophysiol, May 1, 2003; 89(5): 2449 - 2458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hurtado, S. Borges, and M. Wilson Na+-Ca2+ Exchanger Controls the Gain of the Ca2+ Amplifier in the Dendrites of Amacrine Cells J Neurophysiol, November 1, 2002; 88(5): 2765 - 2777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Solessio, J. Vigh, N. Cuenca, K. Rapp, and E. M Lasater Membrane properties of an unusual intrinsically oscillating, wide-field teleost retinal amacrine cell J. Physiol., November 1, 2002; 544(3): 831 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Harris, M. G. Coulombe, and M. B. Feller Dissociated Retinal Neurons Form Periodically Active Synaptic Circuits J Neurophysiol, July 1, 2002; 88(1): 188 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Charpak, J. Mertz, E. Beaurepaire, L. Moreaux, and K. Delaney Odor-evoked calcium signals in dendrites of rat mitral cells PNAS, January 10, 2001; (2001) 21422798. [Abstract] [Full Text]
|
|
|
|
|
|
S.-I. Watanabe, A. Koizumi, S. Matsunaga, J. W. Stocker, and A. Kaneko GABA-Mediated Inhibition Between Amacrine Cells in the Goldfish Retina J Neurophysiol, October 1, 2000; 84(4): 1826 - 1834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Charpak, J. Mertz, E. Beaurepaire, L. Moreaux, and K. Delaney Odor-evoked calcium signals in dendrites of rat mitral cells PNAS, January 30, 2001; 98(3): 1230 - 1234. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
