JN AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 81: 3096-3099, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (33)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hjelmstad, G. O.
Right arrow Articles by Malenka, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hjelmstad, G. O.
Right arrow Articles by Malenka, R. C.

The Journal of Neurophysiology Vol. 81 No. 6 June 1999, pp. 3096-3099
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

Lack of AMPA Receptor Desensitization During Basal Synaptic Transmission in the Hippocampal Slice

Gregory O. Hjelmstad,1,2 John T. R. Isaac,1 Roger A. Nicoll,2,3 and Robert C. Malenka1,2

Departments of  1Psychiatry,  2Physiology, and  3Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143

Hjelmstad, Gregory O., John T. R. Isaac, Roger A. Nicoll, and Robert C. Malenka. Lack of AMPA Receptor Desensitization During Basal Synaptic Transmission in the Hippocampal Slice. J. Neurophysiol. 81: 3096-3099, 1999.Lack of AMPA receptor desensitization during basal synaptic transmission in the hippocampal slice. Excitatory postsynaptic currents in the CA1 region of rat hippocampal slices are mediated primarily by alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in response to synaptically released glutamate. Outside-out patches from pyramidal cells in this region have shown that AMPA receptors are desensitized by short (1 ms) pulses of glutamate. We have taken a number of approaches to ask whether synaptic receptors desensitize in response to synaptically released glutamate in the slice. Recordings with paired pulses and minimal stimulation conditions that are presumably activating only a single release site do not show evidence for desensitization. Furthermore, cyclothiazide, a drug that blocks desensitization, does not alter paired-pulse ratios even under conditions of high probability of release, which should maximize desensitization. These results suggest that synaptic receptors do not desensitize in response to synaptically released glutamate during basal synaptic transmission.




This article has been cited by other articles:


Home page
 ScienceHome page
M. Heine, L. Groc, R. Frischknecht, J.-C. Beique, B. Lounis, G. Rumbaugh, R. L. Huganir, L. Cognet, and D. Choquet
Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission
Science, April 11, 2008; 320(5873): 201 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. A. DiGregorio, J. S. Rothman, T. A. Nielsen, and R. A. Silver
Desensitization Properties of AMPA Receptors at the Cerebellar Mossy Fiber Granule Cell Synapse
J. Neurosci., August 1, 2007; 27(31): 8344 - 8357.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. J. Crowley, A. G. Carter, and W. G. Regehr
Fast Vesicle Replenishment and Rapid Recovery from Desensitization at a Single Synaptic Release Site
J. Neurosci., May 16, 2007; 27(20): 5448 - 5460.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Lasztoczi and J. Kardos
Cyclothiazide Prolongs Low [Mg2+]-Induced Seizure-Like Events
J Neurophysiol, December 1, 2006; 96(6): 3538 - 3544.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. Ricci-Tersenghi, F. Minneci, E. Sola, E. Cherubini, and L. Maggi
Multivesicular Release at Developing Schaffer Collateral-CA1 Synapses: An Analytic Approach to Describe Experimental Data
J Neurophysiol, July 1, 2006; 96(1): 15 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. A. Klyachko and C. F. Stevens
Temperature-dependent shift of balance among the components of short-term plasticity in hippocampal synapses.
J. Neurosci., June 28, 2006; 26(26): 6945 - 6957.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Y. C. Wong, B. Billups, J. Johnston, R. J. Evans, and I. D. Forsythe
Endogenous Activation of Adenosine A1 Receptors, but Not P2X Receptors, During High-Frequency Synaptic Transmission at the Calyx of Held
J Neurophysiol, June 1, 2006; 95(6): 3336 - 3342.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Y. Sun, S. A Lyons, and L. E Dobrunz
Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats
J. Physiol., November 1, 2005; 568(3): 815 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Li, A. E. Bandrowski, and D. A. Prince
Cortical Injury Affects Short-Term Plasticity of Evoked Excitatory Synaptic Currents
J Neurophysiol, January 1, 2005; 93(1): 146 - 156.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Raghavachari and J. E. Lisman
Properties of Quantal Transmission at CA1 Synapses
J Neurophysiol, October 1, 2004; 92(4): 2456 - 2467.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. H. Wu, C. L. Ma, and J. B. Kelly
Contribution of AMPA, NMDA, and GABAA Receptors to Temporal Pattern of Postsynaptic Responses in the Inferior Colliculus of the Rat
J. Neurosci., May 12, 2004; 24(19): 4625 - 4634.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Chen, N. C. Harata, and R. W. Tsien
From the Cover: Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses
PNAS, January 27, 2004; 101(4): 1063 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. F. Jackson, D. T. Joo, A. A. Al-Mahrouki, B. A. Orser, and J. F. Macdonald
Desensitization of {alpha}-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Facilitates Use-Dependent Inhibition by Pentobarbital
Mol. Pharmacol., August 1, 2003; 64(2): 395 - 406.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Y. C. Wong, B. P. Graham, B. Billups, and I. D. Forsythe
Distinguishing between Presynaptic and Postsynaptic Mechanisms of Short-Term Depression during Action Potential Trains
J. Neurosci., June 15, 2003; 23(12): 4868 - 4877.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. C. Arai, Y.-F. Xia, M. Kessler, D. Phillips, R. Chamberlin, R. Granger, and G. Lynch
Effects of 5'-Alkyl-Benzothiadiazides on (R,S)-alpha -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Biophysics and Synaptic Responses
Mol. Pharmacol., September 1, 2002; 62(3): 566 - 577.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. Hanse and B. Gustafsson
Factors explaining heterogeneity in short-term synaptic dynamics of hippocampal glutamatergic synapses in the neonatal rat
J. Physiol., November 15, 2001; 537(1): 141 - 149.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Hanse and B. Gustafsson
Paired-Pulse Plasticity at the Single Release Site Level: An Experimental and Computational Study
J. Neurosci., November 1, 2001; 21(21): 8362 - 8369.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Barbour
An Evaluation of Synapse Independence
J. Neurosci., October 15, 2001; 21(20): 7969 - 7984.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. C. Arai, M. Kessler, G. Rogers, and G. Lynch
Effects of the Potent Ampakine CX614 on Hippocampal and Recombinant AMPA Receptors: Interactions with Cyclothiazide and GYKI 52466
Mol. Pharmacol., October 1, 2000; 58(4): 802 - 813.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
D. Parker
Activity and Calcium-Dependent Mechanisms Maintain Reliable Interneuron Synaptic Transmission in a Rhythmic Neural Network
J. Neurosci., March 1, 2000; 20(5): 1754 - 1766.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online