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The Journal of Neurophysiology Vol. 82 No. 1 July 1999, pp. 115-122
Copyright ©1999 by the American Physiological Society
1Department of Biology, 2Department of Physics, 3Institute for Nonlinear Science, and 4Marine Physical Laboratory, Scripps Institution of Oceanography, University of California, San Diego, California 92093-0402
Elson, Robert C.,
Ramon Huerta,
Henry D. I. Abarbanel,
Mikhail I. Rabinovich, and
Allen I. Selverston.
Dynamic Control of Irregular Bursting in an Identified Neuron of
an Oscillatory Circuit. J. Neurophysiol. 82: 115-122, 1999.
In the oscillatory circuits known as
central pattern generators (CPGs), most synaptic connections are
inhibitory. We have assessed the effects of inhibitory synaptic input
on the dynamic behavior of a component neuron of the pyloric CPG in the
lobster stomatogastric ganglion. Experimental perturbations were
applied to the single, lateral pyloric neuron (LP), and the resulting voltage time series were analyzed using an entropy measure obtained from power spectra. When isolated from phasic inhibitory input, LP
generates irregular spiking-bursting activity. Each burst begins in a
relatively stereotyped manner but then evolves with exponentially increasing variability. Periodic, depolarizing current pulses are poor
regulators of this activity, whereas hyperpolarizing pulses exert a
strong, frequency-dependent regularizing action. Rhythmic inhibitory
inputs from presynaptic pacemaker neurons also regularize the bursting.
These inputs 1) reset LP to a similar state at each
cycle, 2) extend and further stabilize the initial, quasi-stable phase of its bursts, and 3) at sufficiently
high frequencies terminate ongoing bursts before they become unstable. The dynamic time frame for stabilization overlaps the normal frequency range of oscillations of the pyloric CPG. Thus, in this oscillatory circuit, the interaction of rhythmic inhibitory input with intrinsic burst properties affects not only the phasing, but also the dynamic stability of neural activity.
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