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The Journal of Neurophysiology Vol. 82 No. 1 July 1999, pp. 34-41
Copyright ©1999 by the American Physiological Society
Department of Neurology, University of Munich, D-81377 Munich, Germany
Siebold, C.,
J. F. Kleine,
L. Glonti,
T. Tchelidze, and
U. Büttner.
Fastigial Nucleus Activity During Different Frequencies and
Orientations of Vertical Vestibular Stimulation in the Monkey. J. Neurophysiol. 82: 34-41, 1999.
Neurons in the rostral part of the fastigial nucleus (FN) respond to
vestibular stimulation but are not related to eye movements. To
understand the precise role of these vestibular-only neurons in the
central processing of vestibular signals, unit activity in the FN of
alert monkeys (Macaca mulatta) was recorded. To induce vestibular stimulation, the monkey was rotated sinusoidally around an
earth-fixed horizontal axis at stimulus frequencies between 0.06 (±15°) and 1.4 Hz (±7.5°). During stimulation head orientation was changed continuously, allowing for roll, pitch, and intermediate planes of orientation. At a frequency of 0.6 Hz, 59% of the neurons had an optimal response orientation (ORO) and a null response (i.e., no
modulation) 90° apart. The phase of neuronal response was constant
except for a steep shift of 180° around the null response. This group
I response is compatible with a semicircular canal input, canal
convergence, or a single otolith input. Several other features
indicated more complex responses, including spatiotemporal convergence
(STC). 1) For 35% of the responses at 0.6 Hz, phase changes were gradual with different orientations. Fifteen percent of
these had a null response (group II), and 20% showed only a minimal
response but no null response (group III). The remaining responses
(6%), classified as group IV, were characterized by a constant
sensitivity at different orientations in most instances. 2) For the vast majority of neurons, the stimulus
frequency determined the response group, i.e., an individual neuron
could show a group I response at one frequency and a group II (III or
IV) response at another frequency. 3) ORO changed with
frequency by >45° for 44% of the neurons. 4)
Although phase changes at different frequencies were close to head
velocity (±45°) or head position (±45°) for most neurons, they
exceeded 90° for 29% of the neurons between 0.1 and 1.0 Hz. In most
cases, this was a phase advance. The change in sensitivity with change
in frequency showed a similar pattern for all neurons; the average
sensitivity increased from 1.24 imp · s
1 · deg1 at 0.1 Hz to 2.97 imp · s1
· deg1 at 1.0 Hz. These data demonstrate that only an
analysis based on measurements at different frequencies and
orientations reveals a number of complex features. They moreover
suggest that for the vast majority of neurons several sources of canal
and otolith information interact at this central stage of vestibular
information processing.
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