| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 82 No. 1 July 1999, pp. 370-381
Copyright ©1999 by the American Physiological Society
Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
Pearson, K. G.,
K. Fouad, and
J. E. Misiaszek.
Adaptive Changes in Motor Activity Associated With Functional
Recovery Following Muscle Denervation in Walking Cats. J. Neurophysiol. 82: 370-381, 1999.
In this
investigation we examined the changes in the pattern of activity in the
medial gastrocnemius (MG) muscle in walking cats following transection
of the nerves innervating synergist muscles (lateral gastrocnemius,
soleus, and plantaris). Immediately following the nerve transections,
there was a large increase in ankle flexion during early stance (from
~10 to ~30°) and a marked increase in the magnitude of the MG
bursts during stance. We attribute this increase in the magnitude of
the MG bursts to an increase in afferent feedback from the abnormally
stretched MG muscle. During the week after the nerve transections,
there was a progressive decrease in ankle yield. This improvement in
ankle function was correlated with an increase in magnitude of two
components of the MG bursts; the initial component starting during late
swing and ending ~40 ms after ground contact, and a late component
associated with stance. The time courses of the increases in the
initial and late components of the MG bursts were different. Large and significant increases in the late component occurred the day after the
nerve transections, whereas increases in the initial component occurred
more gradually. This difference in time course was reflected in the
kinematics of ankle movement. Over the first few days after the nerve
transections, improvement in ankle movement occurred primarily late in
the stance phase, and there was little change in ankle yield during
early stance. At 1 wk, however, there was a significant reduction in
ankle yield during early stance. This decreased yield was most likely
due to an increase in stiffness of the MG muscle at the time of ground
contact resulting from the increase in magnitude of the initial
component of the MG bursts. The increases in the magnitude of the
initial and late components of the MG bursts, as well as the
improvement in ankle function, depended on use of the leg. All these
changes were delayed by immobilizing the leg for 6 days in an extended
position. We discuss possible mechanisms underlying the increase in the
magnitude of the MG bursts and propose that proprioceptive signals from
the stretched MG muscles provide an error signal for rescaling the magnitude of the centrally generated initial component. Our data support the concept that proprioceptive feedback functions to scale the
magnitude of feed-forward motor commands to ensure they are appropriate
for the biomechanical properties of the musculoskeletal system.
This article has been cited by other articles:
|
|
 |
|
  A. Frigon and S. Rossignol Locomotor and Reflex Adaptation After Partial Denervation of Ankle Extensors in Chronic Spinal Cats J Neurophysiol, September 1, 2008; 100(3): 1513 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Bichler, S. T. Nakanishi, Q.-B. Wang, M. J. Pinter, M. M. Rich, and T. C. Cope Enhanced Transmission at a Spinal Synapse Triggered In Vivo by an Injury Signal Independent of Altered Synaptic Activity J. Neurosci., November 21, 2007; 27(47): 12851 - 12859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Frigon and S. Rossignol Plasticity of Reflexes From the Foot During Locomotion After Denervating Ankle Extensors in Intact Cats J Neurophysiol, October 1, 2007; 98(4): 2122 - 2132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L Segal Use of Imaging to Assess Normal and Adaptive Muscle Function Physical Therapy, June 1, 2007; 87(6): 704 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rossignol, R. Dubuc, and J.-P. Gossard Dynamic Sensorimotor Interactions in Locomotion Physiol Rev, January 1, 2006; 86(1): 89 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bretzner and T. Drew Changes in Corticospinal Efficacy Contribute to the Locomotor Plasticity Observed After Unilateral Cutaneous Denervation of the Hindpaw in the Cat J Neurophysiol, October 1, 2005; 94(4): 2911 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, X. Y. Chen, L. B. Jakeman, G. Schalk, B. T. Stokes, and J. R. Wolpaw The Interaction of a New Motor Skill and an Old One: H-Reflex Conditioning and Locomotion in Rats J. Neurosci., July 20, 2005; 25(29): 6898 - 6906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bretzner and T. Drew Contribution of the Motor Cortex to the Structure and the Timing of Hindlimb Locomotion in the Cat: A Microstimulation Study J Neurophysiol, July 1, 2005; 94(1): 657 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Carrasco, M. M. Rich, Q. Wang, T. C. Cope, and M. J. Pinter Activity-Driven Synaptic and Axonal Degeneration in Canine Motor Neuron Disease J Neurophysiol, August 1, 2004; 92(2): 1175 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Campos, Z. Meng, G. Hu, D. T. W. Chiu, R. T. Ambron, and J. H. Martin Engineering Novel Spinal Circuits to Promote Recovery after Spinal Injury J. Neurosci., March 3, 2004; 24(9): 2090 - 2101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. C. Pang, T. Lam, and J. F. Yang Infants Adapt Their Stepping to Repeated Trip-Inducing Stimuli J Neurophysiol, October 1, 2003; 90(4): 2731 - 2740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M.J.I. Huyghues-Despointes, T. C. Cope, and T. R. Nichols Intrinsic Properties and Reflex Compensation in Reinnervated Triceps Surae Muscles of the Cat: Effect of Activation Level J Neurophysiol, September 1, 2003; 90(3): 1537 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M.J.I. Huyghues-Despointes, T. C. Cope, and T. R. Nichols Intrinsic Properties and Reflex Compensation in Reinnervated Triceps Surae Muscles of the Cat: Effect of Movement History J Neurophysiol, September 1, 2003; 90(3): 1547 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lam, C. Wolstenholme, and J. F. Yang How Do Infants Adapt to Loading of the Limb During the Swing Phase of Stepping? J Neurophysiol, April 1, 2003; 89(4): 1920 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Misiaszek and K. G. Pearson Adaptive Changes in Locomotor Activity Following Botulinum Toxin Injection in Ankle Extensor Muscles of Cats J Neurophysiol, January 1, 2002; 87(1): 229 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. G. Bouyer, P. J. Whelan, K. G. Pearson, and S. Rossignol Adaptive Locomotor Plasticity in Chronic Spinal Cats after Ankle Extensors Neurectomy J. Neurosci., May 15, 2001; 21(10): 3531 - 3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkler, G. A. S. Metz, O. Raineteau, V. Dietz, M. E. Schwab, and K. Fouad Locomotor Recovery in Spinal Cord-Injured Rats Treated with an Antibody Neutralizing the Myelin-Associated Neurite Growth Inhibitor Nogo-A J. Neurosci., May 15, 2001; 21(10): 3665 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. R. Edgerton and R. R. Roy Physiology of a Microgravity Environment: Invited Review: Gravitational biology of the neuromotor systems: a perspective to the next era J Appl Physiol, September 1, 2000; 89(3): 1224 - 1231. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
