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J Neurophysiol 82: 478-483, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 82 No. 1 July 1999, pp. 478-483
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

NPY Inhibits Glutamatergic Excitation in the Epileptic Human Dentate Gyrus

Peter R. Patrylo, Anthony N. van den Pol, Dennis D. Spencer, and Anne Williamson

Department of Neurosurgery, Yale University Medical School, New Haven, Connecticut 06520

Patrylo, Peter R., Anthony N. van den Pol, Dennis D. Spencer, and Anne Williamson. NPY Inhibits Glutamatergic Excitation in the Epileptic Human Dentate Gyrus. J. Neurophysiol. 82: 478-483, 1999.Neuropeptide Y (NPY) has been shown to depress hyperexcitable activity that has been acutely induced in the normal rat brain. To test the hypothesis that NPY can also reduce excitability in the chronically epileptic human brain, we recorded intracellularly from dentate granule cells in hippocampal slices from patients with hippocampal seizure onset. NPY had a potent and long-lasting inhibitory action on perforant path-evoked excitatory responses. In comparison, the group 3 metabotropic glutamate receptor agonist L-2-amino-4-phosphonobutyric acid (L-AP4) evoked a mild and transient decrease. NPY-containing axons were found throughout the hippocampus, and in many epileptic patients were reorganized, particularly in the dentate molecular layer. NPY may therefore play a beneficial role in reducing granule cell excitability in chronically epileptic human tissue, and subsequently limit seizure severity.




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