| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 82 No. 1 July 1999, pp. 489-494
Copyright ©1999 by the American Physiological Society
RAPID COMMUNICATION
Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201
Aroniadou-Anderjaska, Vassiliki,
Matthew Ennis, and
Michael T. Shipley.
Dendrodendritic Recurrent Excitation in Mitral Cells of the Rat
Olfactory Bulb. J. Neurophysiol. 82: 489-494, 1999.
Most neuronal interactions within the olfactory
bulb network are mediated by dendrodendritic synapses. Dendritic
transmitter release potentially could affect the parent dendrite as
well as local neuronal elements that have receptors for the released
transmitter. Here we report that under conditions that facilitate
N-methyl-D-aspartate (NMDA) receptor activity
(reduced GABAA inhibition and extracellular Mg2+), a single action potential evoked by brief
intracellular current pulses in mitral cells is followed by a prolonged
depolarization, which is blocked by an NMDA receptor antagonist. This
depolarization also is evoked by a presumed calcium spike in the
presence of tetrodotoxin. A similar NMDA-receptor-dependent prolonged
depolarization is elicited by stimulation of the lateral olfactory
tract at current intensities subthreshold for antidromic activation of
the recorded neuron. These observations suggest that glutamate released
from the dendrites of mitral cells excites the same and neighboring mitral cell dendrites. Further evidence suggests that both the apical
and lateral dendrites of mitral cells participate in this recurrent
excitation. These dendrodendritic interactions may play a role in the
prolonged, NMDA-receptor-dependent depolarization of mitral/tufted
cells evoked by olfactory nerve stimulation.
This article has been cited by other articles:
|
|
 |
|
  N. Pirez and M. Wachowiak In Vivo Modulation of Sensory Input to the Olfactory Bulb by Tonic and Activity-Dependent Presynaptic Inhibition of Receptor Neurons J. Neurosci., June 18, 2008; 28(25): 6360 - 6371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Tyler, G. C. Petzold, S. K. Pal, and V. N. Murthy Experience-Dependent Modification of Primary Sensory Synapses in the Mammalian Olfactory Bulb J. Neurosci., August 29, 2007; 27(35): 9427 - 9438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Rubin and T. A. Cleland Dynamical Mechanisms of Odor Processing in Olfactory Bulb Mitral Cells J Neurophysiol, August 1, 2006; 96(2): 555 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yuan and T. Knopfel Olfactory Nerve Stimulation-Evoked mGluR1 Slow Potentials, Oscillations, and Calcium Signaling in Mouse Olfactory Bulb Mitral Cells J Neurophysiol, May 1, 2006; 95(5): 3097 - 3104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yuan and T. Knopfel Olfactory Nerve Stimulation-Induced Calcium Signaling in the Mitral Cell Distal Dendritic Tuft J Neurophysiol, April 1, 2006; 95(4): 2417 - 2426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ennis, M. Zhu, T. Heinbockel, and A. Hayar Olfactory Nerve-Evoked, Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Rat Olfactory Bulb Mitral Cells J Neurophysiol, April 1, 2006; 95(4): 2233 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Christie and G. L. Westbrook Lateral excitation within the olfactory bulb. J. Neurosci., February 22, 2006; 26(8): 2269 - 2277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wachowiak, J. P. McGann, P. M. Heyward, Z. Shao, A. C. Puche, and M. T. Shipley Inhibition of Olfactory Receptor Neuron Input to Olfactory Bulb Glomeruli Mediated by Suppression of Presynaptic Calcium Influx J Neurophysiol, October 1, 2005; 94(4): 2700 - 2712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-M. Lledo, G. Gheusi, and J.-D. Vincent Information Processing in the Mammalian Olfactory System Physiol Rev, January 1, 2005; 85(1): 281 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Heinbockel, P. Heyward, F. Conquet, and M. Ennis Regulation of Main Olfactory Bulb Mitral Cell Excitability by Metabotropic Glutamate Receptor mGluR1 J Neurophysiol, November 1, 2004; 92(5): 3085 - 3096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Balu, P. Larimer, and B. W. Strowbridge Phasic Stimuli Evoke Precisely Timed Spikes in Intermittently Discharging Mitral Cells J Neurophysiol, August 1, 2004; 92(2): 743 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hayar, S. Karnup, M. Ennis, and M. T. Shipley External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity J. Neurosci., July 28, 2004; 24(30): 6676 - 6685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wachowiak, W. Denk, and R. W. Friedrich Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging PNAS, June 15, 2004; 101(24): 9097 - 9102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Friedrich and G. Laurent Dynamics of Olfactory Bulb Input and Output Activity During Odor Stimulation in Zebrafish J Neurophysiol, June 1, 2004; 91(6): 2658 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hayar, S. Karnup, M. T. Shipley, and M. Ennis Olfactory Bulb Glomeruli: External Tufted Cells Intrinsically Burst at Theta Frequency and Are Entrained by Patterned Olfactory Input J. Neurosci., February 4, 2004; 24(5): 1190 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lowe Flash Photolysis Reveals a Diversity of Ionotropic Glutamate Receptors on the Mitral Cell Somatodendritic Membrane J Neurophysiol, September 1, 2003; 90(3): 1737 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Heyward, M. Ennis, A. Keller, and M. T. Shipley Membrane Bistability in Olfactory Bulb Mitral Cells J. Neurosci., July 15, 2001; 21(14): 5311 - 5320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-A. Salin, P.-M. Lledo, J.-D. Vincent, and S. Charpak Dendritic Glutamate Autoreceptors Modulate Signal Processing in Rat Mitral Cells J Neurophysiol, March 1, 2001; 85(3): 1275 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Isaacson Mechanisms governing dendritic gamma -aminobutyric acid (GABA) release in the rat olfactory bulb PNAS, December 14, 2000; (2000) 21445798. [Abstract] [Full Text]
|
|
|
|
|
|
V. Aroniadou-Anderjaska, F.-M. Zhou, C. A. Priest, M. Ennis, and M. T. Shipley Tonic and Synaptically Evoked Presynaptic Inhibition of Sensory Input to the Rat Olfactory Bulb Via GABAB Heteroreceptors J Neurophysiol, September 1, 2000; 84(3): 1194 - 1203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Friedman and B. W. Strowbridge Functional Role of NMDA Autoreceptors in Olfactory Mitral Cells J Neurophysiol, July 1, 2000; 84(1): 39 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sassoe-Pognetto and O. P. Ottersen Organization of Ionotropic Glutamate Receptors at Dendrodendritic Synapses in the Rat Olfactory Bulb J. Neurosci., March 15, 2000; 20(6): 2192 - 2201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Carlson, M. T. Shipley, and A. Keller Long-Lasting Depolarizations in Mitral Cells of the Rat Olfactory Bulb J. Neurosci., March 1, 2000; 20(5): 2011 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Isaacson Mechanisms governing dendritic gamma -aminobutyric acid (GABA) release in the rat olfactory bulb PNAS, January 2, 2001; 98(1): 337 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Didier, A. Carleton, J. G. Bjaalie, J.-D. Vincent, O. P. Ottersen, J. Storm-Mathisen, and P.-M. Lledo A dendrodendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb PNAS, May 22, 2001; 98(11): 6441 - 6446. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
