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J Neurophysiol 82: 508-511, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 82 No. 1 July 1999, pp. 508-511
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

Oxidative Downmodulation of the Transient K-Current IA by Intracellular Arachidonic Acid in Rat Hippocampal Neurons

Katrin Bittner and Wolfgang Müller

AG Molekulare Zellphysiologie, Institut für Physiologie der Charité, D-10117 Berlin, Germany

Bittner, Katrin and Wolfgang Müller. Oxidative Downmodulation of the Transient K-Current IA by Intracellular Arachidonic Acid in Rat Hippocampal Neurons. J. Neurophysiol. 82: 508-511, 1999.Membrane-permeable arachidonic acid (AA) is liberated in a Ca2+-dependent way inside cells. By using whole cell patch clamp we show that intracellular AA (1 pM) selectively reduces IA in rat hippocampal neurons, whereas extracellular application requires a 106-fold concentration. The nonmetabolized AA analogue ETYA mimics the effect of AA that is blocked by ascorbic acid or intracellular glutathione, suggesting an intracellular oxidative mechanism. We conclude that intracellular AA is extremely potent in reducing IA by an oxidative mechanism, particularly during oxidative stress.




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