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J Neurophysiol 82: 1086-1090, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 82 No. 2 August 1999, pp. 1086-1090
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

Errors of Memory-Guided Saccades in Humans With Lesions of the Frontal Eye Field and the Dorsolateral Prefrontal Cortex

Christoph J. Ploner,1,2 Sophie Rivaud-Péchoux,1 Bertrand M. Gaymard,1 Yves Agid,1 and Charles Pierrot-Deseilligny1

 1Institut National de la Santé et de la Recherche Médicale U. 289 and Service de Neurologie, Hôpital de la Salpêtrière, F-75651 Paris Cedex 13, France; and  2Klinik für Neurologie, Charité, D-10117 Berlin, Germany

Ploner, Christoph J., Sophie Rivaud-Péchoux, Bertrand M. Gaymard, Yves Agid, and Charles Pierrot-Deseilligny. Errors of Memory-Guided Saccades in Humans With Lesions of the Frontal Eye Field and the Dorsolateral Prefrontal Cortex. J. Neurophysiol. 82: 1086-1090, 1999. Behavioral studies in monkeys and humans suggest that systematic and variable errors of memory-guided saccades reflect distinct neuronal computations in primate spatial memory. We recorded memory-guided saccades with a 2-s delay in three patients with unilateral ischemic lesions of the frontal eye field and in three patients with unilateral ischemic lesions of the frontal eye field and the dorsolateral prefrontal cortex. Results suggest that systematic errors of memory-guided saccades originate in the frontal eye field and variable errors in the dorsolateral prefrontal cortex. These data are the first human lesion data to support the hypothesis that these regions provide functionally distinct contributions to spatial short-term memory.




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