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The Journal of Neurophysiology Vol. 82 No. 2 August 1999, pp. 593-610
Copyright ©1999 by the American Physiological Society
Department of Zoology, University of Texas at Austin, Austin, Texas 78712
Klug, Achim,
Eric E. Bauer, and
George D. Pollak.
Multiple Components of Ipsilaterally Evoked Inhibition in the
Inferior Colliculus. J. Neurophysiol. 82: 593-610, 1999. The central nucleus of the inferior colliculus
(ICc) receives a large number of convergent inputs that are both
excitatory and inhibitory. Although excitatory inputs typically are
evoked by stimulation of the contralateral ear, inhibitory inputs can be recruited by either ear. Here we evaluate ipsilaterally evoked inhibition in single ICc cells in awake Mexican free-tailed bats. The
principal question we addressed concerns the degree to which ipsilateral inhibition at the ICc suppresses contralaterally evoked discharges and thus creates the excitatory-inhibitory (EI) properties of ICc neurons. To study ipsilaterally evoked inhibition, we
iontophoretically applied excitatory neurotransmitters and visualized
the ipsilateral inhibition as a gap in the carpet of background
activity evoked by the transmitters. Ipsilateral inhibition was seen in
86% of ICc cells. The inhibition in most cells had both glycinergic
and GABAergic components that could be blocked by the iontophoretic application of bicuculline and strychnine. In 80% of the cells that
were inhibited, the ipsilateral inhibition and contralateral excitation
were temporally coincident. In many of these cells, the ipsilateral
inhibition suppressed contralateral discharges and thus generated the
cell's EI property in the ICc. In other cells, the ipsilateral
inhibition was coincident with the initial portion of the excitation,
but the inhibition was only 2-4 ms in duration and suppressed only the
first few contralaterally evoked discharges. The suppression was so
slight that it often could not be detected as a decrease in the spike
count generated by increasing ipsilateral intensities. Twenty percent
of the cells that expressed inhibition, however, had inhibitory
latencies that were longer than the excitatory latencies. In these
neurons, the inhibition arrived too late to suppress most or any of the
discharges. Finally, in the majority of cells, the ipsilateral
inhibition persisted for tens of milliseconds beyond the duration of
the signal that evoked it. Thus ipsilateral inhibition has multiple components and one or more of these components are typically evoked in
ICc neurons by sound received at the ipsilateral ear.
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