JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 82: 730-735, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perrier, J.-F.
Right arrow Articles by Hounsgaard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perrier, J.-F.
Right arrow Articles by Hounsgaard, J.

The Journal of Neurophysiology Vol. 82 No. 2 August 1999, pp. 730-735
Copyright ©1999 by the American Physiological Society

Ca2+-Activated Nonselective Cationic Current (ICAN) in Turtle Motoneurons

Jean-François Perrier and Jørn Hounsgaard

Department of Medical Physiology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark

Perrier, Jean-François and Jørn Hounsgaard. Ca2+-Activated Nonselective Cationic Current (ICAN) in Turtle Motoneurons. J. Neurophysiol. 82: 730-735, 1999. The presence of a calcium-activated nonspecific cationic (CAN) current in turtle motoneurons and its involvement in plateau potentials, bistability, and windup was investigated by intracellular recordings in a spinal cord slice preparation. In the presence of tetraethylammonium (TEA) and tetrodotoxin (TTX), calcium action potentials evoked by depolarizing current pulses were always followed by an afterdepolarization associated with a decrease in input resistance. The presence of the afterdepolarization depended on the calcium spike and not on membrane potential. Replacement of extracellular sodium by choline or N-methyl-D-glucamine (NMDG) reduced the afterdepolarization, confirming that it was mediated by a CAN current. Plateau potentials and windup were evoked in response to intracellular current pulses in the presence of agonist for different metabotropic receptors. Replacement of extracellular sodium by choline or NMDG did not abolish the generation of plateau potentials, bistability, or windup, showing that Na+ was not the principal charge carrier. It is concluded that plateau potentials, bistability and windup in turtle motoneurons do not depend on a CAN current even though its presence can be detected.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
X. Li and D. J. Bennett
Apamin-Sensitive Calcium-Activated Potassium Currents (SK) Are Activated by Persistent Calcium Currents in Rat Motoneurons
J Neurophysiol, May 1, 2007; 97(5): 3314 - 3330.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Smith and J.-F. Perrier
Intrinsic Properties Shape the Firing Pattern of Ventral Horn Interneurons From the Spinal Cord of the Adult Turtle
J Neurophysiol, November 1, 2006; 96(5): 2670 - 2677.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-F. Perrier and R. Delgado-Lezama
Synaptic Release of Serotonin Induced by Stimulation of the Raphe Nucleus Promotes Plateau Potentials in Spinal Motoneurons of the Adult Turtle
J. Neurosci., August 31, 2005; 25(35): 7993 - 7999.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D Derjean, S Bertrand, F Nagy, and S. J Shefchyk
Plateau potentials and membrane oscillations in parasympathetic preganglionic neurones and intermediolateral neurones in the rat lumbosacral spinal cord
J. Physiol., March 1, 2005; 563(2): 583 - 596.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Alaburda and J. Hounsgaard
Metabotropic Modulation of Motoneurons by Scratch-Like Spinal Network Activity
J. Neurosci., September 24, 2003; 23(25): 8625 - 8629.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Li and D. J. Bennett
Persistent Sodium and Calcium Currents Cause Plateau Potentials in Motoneurons of Chronic Spinal Rats
J Neurophysiol, August 1, 2003; 90(2): 857 - 869.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J.-F. Perrier and J. Hounsgaard
5-HT2 Receptors Promote Plateau Potentials in Turtle Spinal Motoneurons by Facilitating an L-Type Calcium Current
J Neurophysiol, February 1, 2003; 89(2): 954 - 959.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. H. Lee, J. J. Kuo, M. C. Jiang, and C. J. Heckman
Influence of Active Dendritic Currents on Input-Output Processing in Spinal Motoneurons In Vivo
J Neurophysiol, January 1, 2003; 89(1): 27 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. K. Powers and M. D. Binder
Persistent Sodium and Calcium Currents in Rat Hypoglossal Motoneurons
J Neurophysiol, January 1, 2003; 89(1): 615 - 624.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. Martin
Changes in Electrophysiological Properties of Lamprey Spinal Motoneurons During Fictive Swimming
J Neurophysiol, November 1, 2002; 88(5): 2463 - 2476.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. F. Prather, R. K. Powers, and T. C. Cope
Amplification and Linear Summation of Synaptic Effects on Motoneuron Firing Rate
J Neurophysiol, January 1, 2001; 85(1): 43 - 53.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. V. Di Prisco, E. Pearlstein, D. Le Ray, R. Robitaille, and R. Dubuc
A Cellular Mechanism for the Transformation of a Sensory Input into a Motor Command
J. Neurosci., November 1, 2000; 20(21): 8169 - 8176.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. C. Rekling, G. D. Funk, D. A. Bayliss, X.-W. Dong, and J. L. Feldman
Synaptic Control of Motoneuronal Excitability
Physiol Rev, April 1, 2000; 80(2): 767 - 852.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F.-S. Lo and R. R. Mize
Synaptic Regulation of L-Type Ca2+ Channel Activity and Long-Term Depression during Refinement of the Retinocollicular Pathway in Developing Rodent Superior Colliculus
J. Neurosci., February 1, 2000; 20(3): RC58 - RC58.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online