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The Journal of Neurophysiology Vol. 82 No. 2 August 1999, pp. 934-945
Copyright ©1999 by the American Physiological Society
1University Laboratory of Physiology and 2Department of Experimental Psychology, University of Oxford, Oxford OX1 3PT, United Kingdom
van Donkelaar, P.,
J. F. Stein,
R. E. Passingham, and
R. C. Miall.
Neuronal Activity in the Primate Motor Thalamus During Visually
Triggered and Internally Generated Limb Movements. J. Neurophysiol. 82: 934-945, 1999. Single-unit recordings were made from the basal-ganglia- and
cerebellar-receiving areas of the thalamus in two monkeys trained to
make arm movements that were either visually triggered (VT) or
internally generated (IG). A total of 203 neurons displaying movement-related changes in activity were examined in detail. Most of
these cells (69%) showed an increase in firing rate in relation to the
onset of movement and could be categorized according to whether they
fired in the VT task exclusively, in the IG task exclusively, or in
both tasks. The proportion of cells in each category was found to vary
between each of the cerebellar-receiving [oral portion of the ventral
posterolateral nucleus (VPLo) and area X] and basal-ganglia-receiving
[oral portion of the ventral lateral nucleus (VLo) and parvocellular
portion of the ventral anterior nucleus (VApc)] nuclei that were
examined. In particular, in area X the largest group of cells (52%)
showed an increase in activity during the VT task only, whereas in VApc
the largest group of cells (53%) fired in the IG task only. In
contrast to this, relatively high degree of task specificity, in both
VPLo and VLo the largest group of cells (~55%) burst in relation to both tasks. Of the cells that were active in both tasks, a higher proportion were preferentially active in the VT task in VPLo and area
X, and the IG task in VLo and VApc. In addition, cells in all four
nuclei became active earlier relative to movement onset in the IG task
compared with the VT task. These results demonstrate that functional
distinctions do exist in the cerebellar- and basal-ganglia-receiving portions of the primate motor thalamus in relation to the types of cues
used to initiate and control movement. These distinctions are most
clear in area X and VApc, and are much less apparent in VPLo and VLo.
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