| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 82 No. 3 September 1999, pp. 1271-1285
Copyright ©1999 by the American Physiological Society
Departments of 1Otolaryngology
Head and
Neck Surgery, 2Biomedical Engineering, and
3Neuroscience, The Johns Hopkins University,
Baltimore, Maryland 21287-0910; and 4Department
of Anatomy, University of Illinois College of Medicine, Chicago,
Illinois 60612-7300
Lasker, David M.,
Douglas D. Backous,
Anna Lysakowski,
Griffin L. Davis, and
Lloyd B. Minor.
Horizontal Vestibuloocular Reflex Evoked by High-Acceleration
Rotations in the Squirrel Monkey. II. Responses After Canal
Plugging. J. Neurophysiol. 82: 1271-1285, 1999. The horizontal angular vestibuloocular reflex (VOR) evoked by
high-frequency, high-acceleration rotations was studied in four squirrel monkeys after unilateral plugging of the three semicircular canals. During the period (1-4 days) that animals were kept in darkness after plugging, the gain during steps of
acceleration (3,000°/s2, peak velocity = 150°/s)
was 0.61 ± 0.14 (mean ± SD) for contralesional rotations
and 0.33 ± 0.03 for ipsilesional rotations. Within 18-24 h after
animals were returned to light, the VOR gain for contralesional rotations increased to 0.88 ± 0.05, whereas there was only a
slight increase in the gain for ipsilesional rotations to 0.37 ± 0.07. A symmetrical increase in the gain measured at the plateau of head velocity was noted after animals were returned to light. The
latency of the VOR was 8.2 ± 0.4 ms for ipsilesional and 7.1 ± 0.3 ms for contralesional rotations. The VOR evoked by sinusoidal rotations of 0.5-15 Hz, ±20°/s had no significant half-cycle
asymmetries. The recovery of gain for these responses after plugging
was greater at lower than at higher frequencies. Responses to rotations
at higher velocities for frequencies 
4 Hz showed an increase in contralesional half-cycle gain, whereas ipsilesional half-cycle gain
was unchanged. A residual response that appeared to be canal and not
otolith mediated was noted after plugging of all six semicircular canals. This response increased with frequency to reach a gain of
0.23 ± 0.03 at 15 Hz, resembling that predicted based on a reduction of the dominant time constant of the canal to 32 ms after
plugging. A model incorporating linear and nonlinear pathways was used
to simulate the data. The coefficients of this model were determined
from data in animals with intact vestibular function. Selective
increases in the gain for the linear and nonlinear pathways predicted
the changes in recovery observed after canal plugging. An increase in
gain of the linear pathway accounted for the recovery in VOR gain for
both responses at the velocity plateau of the steps of acceleration and
for the sinusoidal rotations at lower peak velocities. The increase in
gain for contralesional responses to steps of acceleration and
sinusoidal rotations at higher frequencies and velocities was due to an
increase in the gain of the nonlinear pathway. This pathway was driven
into inhibitory cutoff at low velocities and therefore made no
contribution for rotations toward the ipsilesional side.
This article has been cited by other articles:
|
|
 |
|
  M. Faulstich, A. M. van Alphen, C. Luo, S. du Lac, and C. I. De Zeeuw Oculomotor Plasticity During Vestibular Compensation Does Not Depend on Cerebellar LTD J Neurophysiol, September 1, 2006; 96(3): 1187 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramachandran and S. G. Lisberger Transformation of Vestibular Signals Into Motor Commands in the Vestibuloocular Reflex Pathways of Monkeys J Neurophysiol, September 1, 2006; 96(3): 1061 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Yakushin, T. Raphan, J. A. Buttner-Ennever, J.-I. Suzuki, and B. Cohen Spatial Properties of Central Vestibular Neurons of Monkeys After Bilateral Lateral Canal Nerve Section J Neurophysiol, December 1, 2005; 94(6): 3860 - 3871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Clendaniel, D. M. Lasker, and L. B. Minor Differential Adaptation of the Linear and Nonlinear Components of the Horizontal Vestibuloocular Reflex in Squirrel Monkeys J Neurophysiol, December 1, 2002; 88(6): 3534 - 3540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arai, S. B. Yakushin, B. Cohen, J.-I. Suzuki, and T. Raphan Spatial Orientation of Caloric Nystagmus in Semicircular Canal-Plugged Monkeys J Neurophysiol, August 1, 2002; 88(2): 914 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Huterer and K. E. Cullen Vestibuloocular Reflex Dynamics During High-Frequency and High-Acceleration Rotations of the Head on Body in Rhesus Monkey J Neurophysiol, July 1, 2002; 88(1): 13 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. LASKER, S. RAMAT, J. P. CAREY, and L. B. MINOR Vergence-Mediated Modulation of the Human Horizontal Angular VOR Provides Evidence of Pathway-Specific Changes in VOR Dynamics Ann. N.Y. Acad. Sci., April 1, 2002; 956(1): 324 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Angelaki, S. D. Newlands, and J. D. Dickman Inactivation of Semicircular Canals Causes Adaptive Increases in Otolith-Driven Tilt Responses J Neurophysiol, March 1, 2002; 87(3): 1635 - 1640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Clendaniel, D. M. Lasker, and L. B. Minor Horizontal Vestibuloocular Reflex Evoked by High-Acceleration Rotations in the Squirrel Monkey. IV. Responses After Spectacle-Induced Adaptation J Neurophysiol, October 1, 2001; 86(4): 1594 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. RABBITT, R. BOYLE, and S. M. HIGHSTEIN Physiology of the Semicircular Canals after Surgical Plugging Ann. N.Y. Acad. Sci., October 1, 2001; 942(1): 274 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. YAKUSHIN, M. DAI, T. RAPHAN, J.-I. SUZUKI, Y. ARAI, and B. COHEN Changes in the Vestibulo-Ocular Reflex after Plugging of the Semicircular Canals Ann. N.Y. Acad. Sci., October 1, 2001; 942(1): 287 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Wiest, J L Demer, J Tian, B T Crane, and R W Baloh Vestibular function in severe bilateral vestibulopathy J. Neurol. Neurosurg. Psychiatry, July 1, 2001; 71(1): 53 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. M. Hess, A. Lysakowski, L. B. Minor, and D. E. Angelaki Central Versus Peripheral Origin of Vestibuloocular Reflex Recovery Following Semicircular Canal Plugging in Rhesus Monkeys J Neurophysiol, December 1, 2000; 84(6): 3078 - 3082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Angelaki and J. D. Dickman Spatiotemporal Processing of Linear Acceleration: Primary Afferent and Central Vestibular Neuron Responses J Neurophysiol, October 1, 2000; 84(4): 2113 - 2132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lasker, T. E. Hullar, and L. B. Minor Horizontal Vestibuloocular Reflex Evoked by High-Acceleration Rotations in the Squirrel Monkey. III. Responses After Labyrinthectomy J Neurophysiol, May 1, 2000; 83(5): 2482 - 2496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Angelaki, S. D. Newlands, and J. D. Dickman Primate Translational Vestibuloocular Reflexes. IV. Changes After Unilateral Labyrinthectomy J Neurophysiol, May 1, 2000; 83(5): 3005 - 3018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Minor, D. M. Lasker, D. D. Backous, and T. E. Hullar Horizontal Vestibuloocular Reflex Evoked by High-Acceleration Rotations in the Squirrel Monkey. I. Normal Responses J Neurophysiol, September 1, 1999; 82(3): 1254 - 1270. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
