JN AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 82: 1311-1316, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (53)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldreich, D.
Right arrow Articles by Simons, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldreich, D.
Right arrow Articles by Simons, D. J.

The Journal of Neurophysiology Vol. 82 No. 3 September 1999, pp. 1311-1316
Copyright ©1999 by the American Physiological Society

Functional Independence of Layer IV Barrels in Rodent Somatosensory Cortex

Daniel Goldreich, Harold T. Kyriazi, and Daniel J. Simons

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261

Goldreich, Daniel, Harold T. Kyriazi, and Daniel J. Simons. Functional Independence of Layer IV Barrels in Rodent Somatosensory Cortex. J. Neurophysiol. 82: 1311-1316, 1999. Layer IV of rodent primary somatosensory cortex is characterized by an array of whisker-related groups of neurons, known as "barrels." Neurons within each barrel respond best to a particular whisker on the contralateral face, and, on deflection of adjacent whiskers, display relatively weak excitation followed by strong inhibition. A prominent hypothesis for the processing of vibrissal information within layer IV is that the multiwhisker receptive fields of barrel neurons reflect interconnections among neighboring barrels. An alternative view is that the receptive field properties of barrel neurons are derived from operations performed on multiwhisker, thalamic inputs by local circuitry within each barrel, independently of neighboring barrels. Here we report that adjacent whisker-evoked excitation and inhibition within a barrel are unaffected by ablation of the corresponding adjacent barrel. In supragranular neurons, on the other hand, excitatory responses to the ablated barrel's associated whisker are substantially reduced. We conclude that the layer IV barrels function as an array of independent parallel processors, each of which individually transforms thalamic afferent input for subsequent processing by horizontally interconnected circuits in other layers.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. Hirata, J. Aguilar, and M. A. Castro-Alamancos
Influence of Subcortical Inhibition on Barrel Cortex Receptive Fields
J Neurophysiol, July 1, 2009; 102(1): 437 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
V. Egger, T. Nevian, and R. M. Bruno
Subcolumnar Dendritic and Axonal Organization of Spiny Stellate and Star Pyramid Neurons within a Barrel in Rat Somatosensory Cortex
Cereb Cortex, April 1, 2008; 18(4): 876 - 889.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Katz, J. E. Heiss, and I. Lampl
Cross-Whisker Adaptation of Neurons in the Rat Barrel Cortex
J. Neurosci., December 20, 2006; 26(51): 13363 - 13372.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Feldmeyer, J. Lubke, and B. Sakmann
Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats
J. Physiol., September 1, 2006; 575(2): 583 - 602.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Shoykhet, P. W. Land, and D. J. Simons
Whisker Trimming Begun at Birth or on Postnatal Day 12 Affects Excitatory and Inhibitory Receptive Fields of Layer IV Barrel Neurons
J Neurophysiol, December 1, 2005; 94(6): 3987 - 3995.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. R. Aguilar and M. A. Castro-Alamancos
Spatiotemporal Gating of Sensory Inputs in Thalamus during Quiescent and Activated States
J. Neurosci., November 23, 2005; 25(47): 10990 - 11002.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Kida, S. Shimegi, and H. Sato
Similarity of Direction Tuning Among Responses to Stimulation of Different Whiskers in Neurons of Rat Barrel Cortex
J Neurophysiol, September 1, 2005; 94(3): 2004 - 2018.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. E. Kwegyir-Afful, R. M. Bruno, D. J. Simons, and A. Keller
The Role of Thalamic Inputs in Surround Receptive Fields of Barrel Neurons
J. Neurosci., June 22, 2005; 25(25): 5926 - 5934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. J. Higley and D. Contreras
Integration of Synaptic Responses to Neighboring Whiskers in Rat Barrel Cortex In Vivo
J Neurophysiol, April 1, 2005; 93(4): 1920 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Ego-Stengel, T. Mello E Souza, V. Jacob, and D. E. Shulz
Spatiotemporal Characteristics of Neuronal Sensory Integration in the Barrel Cortex of the Rat
J Neurophysiol, March 1, 2005; 93(3): 1450 - 1467.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Khatri, J. A. Hartings, and D. J. Simons
Adaptation in Thalamic Barreloid and Cortical Barrel Neurons to Periodic Whisker Deflections Varying in Frequency and Velocity
J Neurophysiol, December 1, 2004; 92(6): 3244 - 3254.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Zhang and K. D. Alloway
Stimulus-Induced Intercolumnar Synchronization of Neuronal Activity in Rat Barrel Cortex: A Laminar Analysis
J Neurophysiol, September 1, 2004; 92(3): 1464 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. P. Pluto, R. D. Lane, and R. W. Rhoades
Local GABA Receptor Blockade Reveals Hindlimb Responses in the SI Forelimb-Stump Representation of Neonatally Amputated Rats
J Neurophysiol, July 1, 2004; 92(1): 372 - 379.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Zhu, R. L. Stornetta, and J. J. Zhu
Chandelier Cells Control Excessive Cortical Excitation: Characteristics of Whisker-Evoked Synaptic Responses of Layer 2/3 Nonpyramidal and Pyramidal Neurons
J. Neurosci., June 2, 2004; 24(22): 5101 - 5108.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. F. Staiger, I. Flagmeyer, D. Schubert, K. Zilles, R. Kotter, and H. J. Luhmann
Functional Diversity of Layer IV Spiny Neurons in Rat Somatosensory Cortex: Quantitative Morphology of Electrophysiologically Characterized and Biocytin Labeled Cells
Cereb Cortex, June 1, 2004; 14(6): 690 - 701.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Wirth and H.-R. Luscher
Spatiotemporal Evolution of Excitation and Inhibition in the Rat Barrel Cortex Investigated With Multielectrode Arrays
J Neurophysiol, April 1, 2004; 91(4): 1635 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. J. Higley and D. Contreras
Nonlinear Integration of Sensory Responses in the Rat Barrel Cortex: An Intracellular Study In Vivo
J. Neurosci., November 12, 2003; 23(32): 10190 - 10200.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Fox, N. Wright, H. Wallace, and S. Glazewski
The Origin of Cortical Surround Receptive Fields Studied in the Barrel Cortex
J. Neurosci., September 10, 2003; 23(23): 8380 - 8391.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Schubert, R. Kotter, K. Zilles, H. J. Luhmann, and J. F. Staiger
Cell Type-Specific Circuits of Cortical Layer IV Spiny Neurons
J. Neurosci., April 1, 2003; 23(7): 2961 - 2970.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. J. Pinto, J. A. Hartings, J. C. Brumberg, and D. J. Simons
Cortical Damping: Analysis of Thalamocortical Response Transformations in Rodent Barrel Cortex
Cereb Cortex, January 1, 2003; 13(1): 33 - 44.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. M. Bruno and D. J. Simons
Feedforward Mechanisms of Excitatory and Inhibitory Cortical Receptive Fields
J. Neurosci., December 15, 2002; 22(24): 10966 - 10975.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Castro-Alamancos
Role of Thalamocortical Sensory Suppression during Arousal: Focusing Sensory Inputs in Neocortex
J. Neurosci., November 15, 2002; 22(22): 9651 - 9655.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Brecht and B. Sakmann
-Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex
J. Physiol., August 15, 2002; 543(1): 49 - 70.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Laaris and A. Keller
Functional Independence of Layer IV Barrels
J Neurophysiol, February 1, 2002; 87(2): 1028 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. A. Brett-Green, C. H. Chen-Bee, and R. D. Frostig
Comparing the Functional Representations of Central and Border Whiskers in Rat Primary Somatosensory Cortex
J. Neurosci., December 15, 2001; 21(24): 9944 - 9954.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. C. H. Petersen and B. Sakmann
Functionally Independent Columns of Rat Somatosensory Barrel Cortex Revealed with Voltage-Sensitive Dye Imaging
J. Neurosci., November 1, 2001; 21(21): 8435 - 8446.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. T. Porter, C. K. Johnson, and A. Agmon
Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex
J. Neurosci., April 15, 2001; 21(8): 2699 - 2710.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
Z. Yang, I. Seif, and M. Armstrong-James
Differences in Somatosensory Processing in S1 Barrel Cortex between Normal and Monoamine Oxidase A Knockout (Tg8) Adult Mice
Cereb Cortex, January 1, 2001; 11(1): 26 - 36.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. C. H. Petersen and B. Sakmann
The Excitatory Neuronal Network of Rat Layer 4 Barrel Cortex
J. Neurosci., October 15, 2000; 20(20): 7579 - 7586.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. S. Petersen and M. E. Diamond
Spatial-Temporal Distribution of Whisker-Evoked Activity in Rat Somatosensory Cortex and the Coding of Stimulus Location
J. Neurosci., August 15, 2000; 20(16): 6135 - 6143.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Prakash, P. Vanderhaeghen, S. Cohen-Cory, J. Frisen, J. G. Flanagan, and R. D. Frostig
Malformation of the Functional Organization of Somatosensory Cortex in Adult Ephrin-A5 Knock-Out Mice Revealed by In Vivo Functional Imaging
J. Neurosci., August 1, 2000; 20(15): 5841 - 5847.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. J. Pinto, J. C. Brumberg, and D. J. Simons
Circuit Dynamics and Coding Strategies in Rodent Somatosensory Cortex
J Neurophysiol, March 1, 2000; 83(3): 1158 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. K. Kelly, G. E. Carvell, J. M. Kodger, and D. J. Simons
Sensory Loss by Selected Whisker Removal Produces Immediate Disinhibition in the Somatosensory Cortex of Behaving Rats
J. Neurosci., October 15, 1999; 19(20): 9117 - 9125.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. C. Brumberg, D. J Pinto, and D. J. Simons
Cortical Columnar Processing in the Rat Whisker-to-Barrel System
J Neurophysiol, October 1, 1999; 82(4): 1808 - 1817.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online