JN Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 82: 1451-1464, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gur, M.
Right arrow Articles by Snodderly, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gur, M.
Right arrow Articles by Snodderly, D. M.

The Journal of Neurophysiology Vol. 82 No. 3 September 1999, pp. 1451-1464
Copyright ©1999 by the American Physiological Society

Physiological Properties of Macaque V1 Neurons are Correlated With Extracellular Spike Amplitude, Duration, and Polarity

Moshe Gur,1,2 Alexander Beylin,1,2 and D. Max Snodderly2,3

 1Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, 32000, Israel;  2Schepens Eye Research Institute, Boston, 02114; and  3Department of Ophthalmology, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115

Gur, Moshe, Alexander Beylin, and D. Max Snodderly. Physiological Properties of Macaque V1 Neurons are Correlated With Extracellular Spike Amplitude, Duration, and Polarity. J. Neurophysiol. 82: 1451-1464, 1999. In the lateral geniculate nucleus (LGN) the large neurons of the magnocellular layers are functionally distinct and anatomically segregated from the small neurons of the parvocellular layers. This segregation of large and small cells is not maintained in the primary visual cortex (V1); instead a heterogeneous mixture of cells occurs, particularly in the output layers. Nevertheless, our results indicate that for the middle and upper layers of V1, cell size remains a predictor of physiological properties. We recorded extracellularly from neurons in V1 of alert monkeys and analyzed the amplitude, duration, and polarity of the action potentials of 199 cells. Of 156 cells that could be assigned to specific cortical layers, 137 (88%) were localized to the middle and upper cortical layers, layer 4 and above. We summarize evidence that the large-amplitude spikes are discharged by large cells, whereas small-amplitude spikes are the action potentials of smaller cells. Large spikes were predominantly negative and of longer duration, whereas small spikes were predominantly positive and briefer. The putative large cells had lower ongoing activity, smaller receptive field activating regions and higher selectivity for stimulus geometry and stimulus motion than the small cells. The contrasting properties of the large and the small cells were illustrated dramatically in simultaneous recordings made from adjacent cells. Our results imply that there may be an anatomic pairing or clustering of small and large cells that could be integral to the functional organization of the cortex. We suggest that the small and the large cells of area V1 have different roles, such that the small cells may shape the properties of the large output cells. If some of the small cells are also output cells, then cell size should be a predictor of the type of information being sent to other brain regions. Because of their high activity and relative ease of stimulation, the small cells also may contribute disproportionately to in vivo images based on metabolic responses such as changes in blood flow.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
I. Diester and A. Nieder
Complementary Contributions of Prefrontal Neuron Classes in Abstract Numerical Categorization
J. Neurosci., July 30, 2008; 28(31): 7737 - 7747.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Gur and D. M. Snodderly
Physiological differences between neurons in layer 2 and layer 3 of primary visual cortex (V1) of alert macaque monkeys
J. Physiol., May 1, 2008; 586(9): 2293 - 2306.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Gur and D. M. Snodderly
Direction selectivity in V1 of alert monkeys: evidence for parallel pathways for motion processing
J. Physiol., December 1, 2007; 585(2): 383 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Zoccolan, M. Kouh, T. Poggio, and J. J. DiCarlo
Trade-Off between Object Selectivity and Tolerance in Monkey Inferotemporal Cortex
J. Neurosci., November 7, 2007; 27(45): 12292 - 12307.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Gur and D. M. Snodderly
High Response Reliability of Neurons in Primary Visual Cortex (V1) of Alert, Trained Monkeys
Cereb Cortex, June 1, 2006; 16(6): 888 - 895.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Gur, I. Kagan, and D. M. Snodderly
Orientation and Direction Selectivity of Neurons in V1 of Alert Monkeys: Functional Relationships and Laminar Distributions
Cereb Cortex, August 1, 2005; 15(8): 1207 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Del Negro, K. Lehongre, and J.-M. Edeline
Selectivity of Canary HVC Neurons for the Bird's Own Song: Modulation by Photoperiodic Conditions
J. Neurosci., May 18, 2005; 25(20): 4952 - 4963.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Kagan, M. Gur, and D. M. Snodderly
Spatial Organization of Receptive Fields of V1 Neurons of Alert Monkeys: Comparison With Responses to Gratings
J Neurophysiol, November 1, 2002; 88(5): 2557 - 2574.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. Goldberg, T. Boraud, S. Maraton, S. N. Haber, E. Vaadia, and H. Bergman
Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease
J. Neurosci., June 1, 2002; 22(11): 4639 - 4653.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. V. Williams, S. G. Rao, and P. S. Goldman-Rakic
The Physiological Role of 5-HT2A Receptors in Working Memory
J. Neurosci., April 1, 2002; 22(7): 2843 - 2854.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online