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J Neurophysiol 82: 1642-1646, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 82 No. 3 September 1999, pp. 1642-1646
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

Injection of Nicotine Into the Superior Colliculus Facilitates Occurrence of Express Saccades in Monkeys

Hiroshi Aizawa,1 Yasushi Kobayashi,1,3 Masaru Yamamoto,1 and Tadashi Isa1,2

 1Department of Integrative Physiology, National Institute for Physiological Sciences;  2Graduate University for Advanced Studies; and  3Core Research for the Evolutional Science and Technology Program (CREST), Myodaiji, Okazaki 444-8585, Japan

Aizawa, Hiroshi, Yasushi Kobayashi, Masaru Yamamoto, and Tadashi Isa. Injection of Nicotine Into the Superior Colliculus Facilitates Occurrence of Express Saccades in Monkeys. J. Neurophysiol. 82: 1642-1646, 1999. To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4-2 µl of 1-100 mM nicotine into the SC, frequency of extremely short latency saccades (express saccades; reaction time = 70-120 ms) dramatically increased, for the saccades the direction and amplitude of which were represented at the location of the injection site on the collicular map. However, no marked change was observed for the relationship between the peak velocities and the amplitudes of saccades. These results suggested that activation of nicotinic acetylcholine receptors in the SC can facilitate initiation but causes no major change in dynamics of visually guided saccades.




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