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J Neurophysiol 82: 2000-2005, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 82 No. 4 October 1999, pp. 2000-2005
Copyright ©1999 by the American Physiological Society

RAPID COMMUNICATION

High-Frequency Dynamics of Regularly Discharging Canal Afferents Provide a Linear Signal for Angular Vestibuloocular Reflexes

Timothy E. Hullar1 and Lloyd B. Minor1,2,3

Departments of  1Otolaryngology-Head and Neck Surgery,  2Biomedical Engineering, and  3Neuroscience, The Johns Hopkins University, Baltimore, Maryland 21287-0910

Hullar, Timothy E. and Lloyd B. Minor. High-Frequency Dynamics of Regularly Discharging Canal Afferents Provide a Linear Signal for Angular Vestibuloocular Reflexes. J. Neurophysiol. 82: 2000-2005, 1999. Regularly discharging vestibular-nerve afferents innervating the semicircular canals were recorded extracellularly in anesthetized chinchillas undergoing high-frequency, high-velocity sinusoidal rotations. In the range from 2 to 20 Hz, with peak velocities of 151°/s at 6 Hz and 52°/s at 20 Hz, 67/70 (96%) maintained modulated discharge throughout the sinusoidal stimulus cycle without inhibitory cutoff or excitatory saturation. These afferents showed little harmonic distortion, no dependence of sensitivity on peak amplitude of stimulation, and no measurable half-cycle asymmetry. A transfer function fitting the data predicts no change in sensitivity (gain) of regularly discharging afferents over the frequencies tested but shows a phase lead with regard to head velocity increasing from 0° at 2 Hz to 30° at 20 Hz. These results indicate that regularly discharging afferents provide a plausible signal to drive the angular vestibuloocular reflex (VOR) even during high-frequency head motion but are not a likely source for nonlinearities present in the VOR.




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