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The Journal of Neurophysiology Vol. 82 No. 5 November 1999, pp. 2163-2170
Copyright ©1999 by the American Physiological Society
Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637
Telgkamp, Petra and
Jan-Marino Ramirez.
Differential Responses of Respiratory Nuclei to Anoxia in
Rhythmic Brain Stem Slices of Mice. J. Neurophysiol. 82: 2163-2170, 1999. The response of the neonatal
respiratory system to hypoxia is characterized by an initial increase
in ventilation, which is followed within a few minutes by a depression
of ventilation below baseline levels. We used the transverse medullary
slice of newborn mice as a model system for central respiratory control
to investigate the effects of short-lasting periods of anoxia.
Extracellular population activity was simultaneously recorded from the
ventral respiratory group (VRG) and the hypoglossus (XII) nucleus (a
respiration-related motor output nucleus). During anoxia, respiratory
frequency was modulated in a biphasic manner and phase-locked in both
the VRG and the XII. The amplitude of phasic respiratory bursts was
increased only in the XII and not in the VRG. This increase in XII
burst amplitude commenced ~1 min after the anoxic onset concomitant with a transient increase in tonic activity. The burst amplitude remained elevated throughout the entire 5 min of anoxia. Inspiratory burst amplitude in the VRG, in contrary, remained constant or even
decreased during anoxia. These findings represent the first simultaneous extracellular cell population recordings of two
respiratory nuclei. They provide important data indicating that rhythm
generation is altered in the VRG without a concomitant alteration in
the VRG burst amplitude, whereas the burst amplitude is modulated only
in the XII nucleus. This has important implications because it suggests
that rhythm generation and motor pattern generation are regulated
separately within the respiratory network.
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