JN AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 82: 2171-2181, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, Y.-C.
Right arrow Articles by Fettiplace, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, Y.-C.
Right arrow Articles by Fettiplace, R.

The Journal of Neurophysiology Vol. 82 No. 5 November 1999, pp. 2171-2181
Copyright ©1999 by the American Physiological Society

Two Components of Transducer Adaptation in Auditory Hair Cells

Yuh-Cherng Wu, A. J. Ricci, and R. Fettiplace

Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706

Wu, Yuh-Cherng, A. J. Ricci, and R. Fettiplace. Two Components of Transducer Adaptation in Auditory Hair Cells. J. Neurophysiol. 82: 2171-2181, 1999. Mechanoelectrical transducer currents in turtle auditory hair cells adapted to maintained stimuli via a Ca2+-dependent mechanism characterized by two time constants of ~1 and 15 ms. The time course of adaptation slowed as the stimulus intensity was raised because of an increased prominence of the second component. The fast component of adaptation had a similar time constant for both positive and negative displacements and was unaffected by the myosin ATPase inhibitors, vanadate and butanedione monoxime. Adaptation was modeled by a scheme in which Ca2+ ions, entering through open transducer channels, bind at two intracellular sites to trigger independent processes leading to channel closure. It was assumed that the second site activates a modulator with 10-fold slower kinetics than the first site. The model was implemented by computing Ca2+ diffusion within a single stereocilium, incorporating intracellular calcium buffers and extrusion via a plasma membrane CaATPase. The theoretical results reproduced several features of the experimental responses, including sensitivity to the concentration of external Ca2+ and intracellular calcium buffer and a dependence on the onset speed of the stimulus. The model also generated damped oscillatory transducer responses at a frequency dependent on the rate constant for the fast adaptive process. The properties of fast adaptation make it unlikely to be mediated by a myosin motor, and we suggest that it may result from Ca2+ binding to the transducer channel or a nearby cytoskeletal element.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. Lelli, Y. Asai, A. Forge, J. R. Holt, and G. S. G. Geleoc
Tonotopic Gradient in the Developmental Acquisition of Sensory Transduction in Outer Hair Cells of the Mouse Cochlea
J Neurophysiol, June 1, 2009; 101(6): 2961 - 2973.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Stepanyan and G. I. Frolenkov
Fast Adaptation and Ca2+ Sensitivity of the Mechanotransducer Require Myosin-XVa in Inner But Not Outer Cochlear Hair Cells
J. Neurosci., April 1, 2009; 29(13): 4023 - 4034.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
W. M. Roberts and M. A. Rutherford
Linear and nonlinear processing in hair cells
J. Exp. Biol., June 1, 2008; 211(11): 1775 - 1780.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Bull.Home page
T. A. Ghanem, K. D. Breneman, R. D. Rabbitt, and H. M. Brown
Ionic Composition of Endolymph and Perilymph in the Inner Ear of the Oyster Toadfish, Opsanus tau
Biol. Bull., February 1, 2008; 214(1): 83 - 90.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Waguespack, F. T. Salles, B. Kachar, and A. J. Ricci
Stepwise Morphological and Functional Maturation of Mechanotransduction in Rat Outer Hair Cells
J. Neurosci., December 12, 2007; 27(50): 13890 - 13902.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
F. Mammano, M. Bortolozzi, S. Ortolano, and F. Anselmi
Ca2+ Signaling in the Inner Ear
Physiology, April 1, 2007; 22(2): 131 - 144.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Jia, P. Dallos, and D. Z. Z. He
Mechanoelectric Transduction of Adult Inner Hair Cells
J. Neurosci., January 31, 2007; 27(5): 1006 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Ficarella, F. Di Leva, M. Bortolozzi, S. Ortolano, F. Donaudy, M. Petrillo, S. Melchionda, A. Lelli, T. Domi, L. Fedrizzi, et al.
A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness
PNAS, January 30, 2007; 104(5): 1516 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. E. Farris, G. B. Wells, and A. J. Ricci
Steady-State Adaptation of Mechanotransduction Modulates the Resting Potential of Auditory Hair Cells, Providing an Assay for Endolymph [Ca2+]
J. Neurosci., November 29, 2006; 26(48): 12526 - 12536.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. R. Phillips, S. Tong, R. Goodyear, G. P. Richardson, and J. L. Cyr
Stereociliary Myosin-1c Receptors Are Sensitive to Calcium Chelation and Absent from Cadherin 23 Mutant Mice.
J. Neurosci., October 18, 2006; 26(42): 10777 - 10788.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. Fettiplace
Active hair bundle movements in auditory hair cells
J. Physiol., October 1, 2006; 576(1): 29 - 36.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Grati, M. E. Schneider, K. Lipkow, E. E. Strehler, R. J. Wenthold, and B. Kachar
Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2.
J. Neurosci., June 7, 2006; 26(23): 6386 - 6395.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. J. Ricci, H. J. Kennedy, A. C. Crawford, and R. Fettiplace
The Transduction Channel Filter in Auditory Hair Cells
J. Neurosci., August 24, 2005; 25(34): 7831 - 7839.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. M. Highstein, R. D. Rabbitt, G. R. Holstein, and R. D. Boyle
Determinants of Spatial and Temporal Coding by Semicircular Canal Afferents
J Neurophysiol, May 1, 2005; 93(5): 2359 - 2370.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Nadrowski, P. Martin, and F. Julicher
Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity
PNAS, August 17, 2004; 101(33): 12195 - 12200.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Si, H. Brodie, P. G. Gillespie, A. E. Vazquez, and E. N. Yamoah
Developmental Assembly of Transduction Apparatus in Chick Basilar Papilla
J. Neurosci., November 26, 2003; 23(34): 10815 - 10826.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. J. Goodyear, P. K. Legan, M. B. Wright, W. Marcotti, A. Oganesian, S. A. Coats, C. J. Booth, C. J. Kros, R. A. Seifert, D. F. Bowen-Pope, et al.
A Receptor-Like Inositol Lipid Phosphatase Is Required for the Maturation of Developing Cochlear Hair Bundles
J. Neurosci., October 8, 2003; 23(27): 9208 - 9219.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Vollrath and R. A. Eatock
Time Course and Extent of Mechanotransducer Adaptation in Mouse Utricular Hair Cells: Comparison With Frog Saccular Hair Cells
J Neurophysiol, October 1, 2003; 90(4): 2676 - 2689.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Martin, D. Bozovic, Y. Choe, and A. J. Hudspeth
Spontaneous Oscillation by Hair Bundles of the Bullfrog's Sacculus
J. Neurosci., June 1, 2003; 23(11): 4533 - 4548.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Bozovic and A. J. Hudspeth
Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog
PNAS, February 4, 2003; 100(3): 958 - 963.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Ricci
Differences in Mechano-Transducer Channel Kinetics Underlie Tonotopic Distribution of Fast Adaptation in Auditory Hair Cells
J Neurophysiol, April 1, 2002; 87(4): 1738 - 1748.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. J. Ricci, A. C. Crawford, and R. Fettiplace
Mechanisms of Active Hair Bundle Motion in Auditory Hair Cells
J. Neurosci., January 1, 2002; 22(1): 44 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
O. P. Hamill and B. Martinac
Molecular Basis of Mechanotransduction in Living Cells
Physiol Rev, April 1, 2001; 81(2): 685 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. R. Holt and D. P. Corey
Two mechanisms for transducer adaptation in vertebrate hair cells
PNAS, October 24, 2000; 97(22): 11730 - 11735.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. J. Hudspeth, Y. Choe, A. D. Mehta, and P. Martin
Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells
PNAS, October 24, 2000; 97(22): 11765 - 11772.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. J. Ricci, A. C. Crawford, and R. Fettiplace
Active Hair Bundle Motion Linked to Fast Transducer Adaptation in Auditory Hair Cells
J. Neurosci., October 1, 2000; 20(19): 7131 - 7142.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online