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The Journal of Neurophysiology Vol. 82 No. 5 November 1999, pp. 2210-2220
Copyright ©1999 by the American Physiological Society
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242
Ozaki, Noriyuki,
J. N. Sengupta, and
G. F. Gebhart.
Mechanosensitive Properties of Gastric Vagal Afferent Fibers
in the Rat. J. Neurophysiol. 82: 2210-2220, 1999. Single, teased fiber recordings were made from the
decentralized right cervical vagus nerve (hyponodal) of the rat. A
total of 67 afferent fibers that responded to gastric distension (GD) were studied: 9 fibers were stimulated by phasic balloon GD, 58 by more
natural fluid GD. All balloon GD-responsive fibers had resting
activity (3.1 imp/s), and 57/58 fluid GD responsive fibers had resting
activity (1.3 imp/s). All balloon GD-responsive fibers exhibited a
dynamic response to phasic distension followed by slow adaptation,
whereas fluid GD-responsive fibers exhibited increasing responses as
intragastric pressure increased, followed typically by slow adaptation.
Responses to graded GD were studied in all fibers, and all gave
increasing responses to increasing pressures (5-60 mmHg). Thresholds
for response varied between 0 and 18 mmHg. Mean response thresholds for
two durations of fluid GD (30 and 60 s) were 5.6 and 3.9 mmHg; the
mean response threshold to phasic balloon GD (30 s duration) was 5.3 mmHg. The potential sensitizing effect of platelet activating factor
(PAF, 50 or 100 ng · kg
1 · min1 for 20 min) infused into the gastric artery was studied in 20 fibers. Fifteen
fibers exhibited an increase in spontaneous activity; intragastric
pressure also slightly increased during PAF infusion. The increase in
activity produced by PAF was attenuated in the presence of the PAF
receptor antagonist WEB 2086. After PAF-induced acute inflammation of
the stomach, three of five fibers studied did not exhibit any change in
response to graded GD. The present study characterized
distension-sensitive afferent fibers in the right cervical vagus
innervating the stomach of the rat by balloon GD and fluid GD. The
results document that all distension-sensitive gastric vagal afferent
fibers encoded the intensity of GD, but none had response thresholds in
what might be considered the noxious range. PAF infusion activated
mechanosensitive gastric vagal afferent fibers, but acute inflammation
produced by PAF did not sensitize responses to GD.
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