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The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 2847-2852
Copyright ©1999 by the American Physiological Society
1Laboratory of Developmental Neurobiology and 2Section on Growth Factors, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; 3William T. Gossett Neurology Labs, Henry Ford Health Sciences Center, Detroit 48202; and 4John D. Dingell Veterans Administration Medical Center, Detroit, Michigan 48201
Jia, Min,
Minxu Li,
Xu-Wen Liu,
Hao Jiang,
Phillip G. Nelson, and
Gordon Guroff.
Voltage-Sensitive Calcium Currents Are Acutely Increased by Nerve
Growth Factor in PC12 Cells. J. Neurophysiol. 82: 2847-2852, 1999. Whole cell calcium currents were
recorded from PC12 cells with the perforated patch technique. Currents
were evoked by step depolarization from a holding potential of 
90 mV.
Nerve growth factor (NGF) increased calcium currents through L-type
calcium channels by >75% within 3-5 min. This increase was inhibited
by K-252a, by nifedipine, and by inhibition or down-regulation of kinase C. Brain-derived neurotrophic factor (BDNF) also increased calcium current, but to a smaller extent. Thus increases in calcium current can be linked to activation of either the high- or the low-affinity nerve growth factor receptor. Increases in presynaptic calcium uptake appear to be a crucial element in the short-term actions
of the neurotrophins on neurotransmitter release leading to long-term
potentiation. Also, the control of calcium uptake is likely to be an
important factor in the long-term actions of the neurotrophins on
neuronal survival and neuronal protection. The present data indicate
that the PC12 cell may be a useful model for studying the effect of the
neurotrophins on calcium uptake.
Deceased 9 July 1999.
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