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The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 2936-2946
Copyright ©1999 by the American Physiological Society
Zentrum Physiologie und Pathophysiologie, Universität Göttingen, 37073 Göttingen, Germany
Lips, Mario B. and
Bernhard U. Keller.
Activity-Related Calcium Dynamics in Motoneurons of the Nucleus
Hypoglossus From Mouse. J. Neurophysiol. 82: 2936-2946, 1999. A quantitative analysis of
activity-related calcium dynamics was performed in motoneurons of the
nucleus hypoglossus in the brain stem slice preparation
from mouse by simultaneous patch-clamp and microfluorometric calcium
measurements. Motoneurons were analyzed under in vitro conditions that
kept them in a functionally intact state represented by rhythmic,
inspiratory-related bursts of excitatory postsynaptic currents and
associated action potential discharges. Bursts of electrical activity
were paralleled by somatic calcium transients resulting from calcium
influx through voltage-activated calcium channels, where each action
potential accounted for a calcium-mediated charge influx around 2 pC
into the somatic compartment. Under in vivo conditions,
rhythmic-respiratory activity in young mice occurred at frequencies up
to 5 Hz, demonstrating the necessity for rapid calcium elevation and
recovery in respiratory-related neurons. The quantitative analysis of
hypoglossal calcium homeostasis identified an average extrusion rate,
but an exceptionally low endogenous calcium binding capacity as
cellular parameters accounting for rapid calcium signaling. Our results
suggest that dynamics of somatic calcium transients 1)
define an upper limit for the maximum frequency of respiratory-related
burst discharges and 2) represent a potentially
dangerous determinant of intracellular calcium profiles during
pathophysiological and/or excitotoxic conditions.
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