JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 82: 2989-2999, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, F.-M.
Right arrow Articles by Hablitz, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, F.-M.
Right arrow Articles by Hablitz, J. J.

The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 2989-2999
Copyright ©1999 by the American Physiological Society

Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex

Fu-Ming Zhou and John J. Hablitz

Department of Neurobiology, University of Alabama, Birmingham, Alabama 35294

Zhou, Fu-Ming and John J. Hablitz. Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex. J. Neurophysiol. 82: 2989-2999, 1999. The cerebral cortex receives an extensive serotonergic (5-hydroxytryptamine, 5-HT) input. Immunohistochemical studies suggest that inhibitory neurons are the main target of 5-HT innervation. In vivo extracellular recordings have shown that 5-HT generally inhibited cortical pyramidal neurons, whereas in vitro studies have shown an excitatory action. To determine the cellular mechanisms underlying the diverse actions of 5-HT in the cortex, we examined its effects on cortical inhibitory interneurons and pyramidal neurons. We found that 5-HT, through activation of 5-HT2A receptors, induced a massive enhancement of spontaneous inhibitory postsynaptic currents (sIPSCs) in pyramidal neurons, lasting for ~6 min. In interneurons, this 5-HT-induced enhancement of sIPSCs was much weaker. Activation of 5-HT2A receptors also increased spontaneous excitatory postsynaptic currents (sEPSCs) in pyramidal neurons. This response desensitized less and at a slower rate. In contrast, 5-HT slightly decreased evoked IPSCs (eIPSCs) and eEPSCs. In addition, 5-HT via 5-HT3 receptors evoked a large and rapidly desensitizing inward current in a subset of interneurons and induced a transient enhancement of sIPSCs. Our results suggest that 5-HT has widespread effects on both interneurons and pyramidal neurons and that a short pulse of 5-HT is likely to induce inhibition whereas the prolonged presence of 5-HT may result in excitation.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M. R. Livesey, M. A. Cooper, T. Z. Deeb, J. E. Carland, J. Kozuska, Tim. G. Hales, J. J. Lambert, and J. A. Peters
Structural Determinants of Ca2+ Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor
J. Biol. Chem., July 11, 2008; 283(28): 19301 - 19313.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. S. Mathew, L. Pozzo-Miller, and J. J. Hablitz
Kainate Modulates Presynaptic GABA Release from Two Vesicle Pools
J. Neurosci., January 16, 2008; 28(3): 725 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-C. Beique, M. Imad, L. Mladenovic, J. A. Gingrich, and R. Andrade
Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex
PNAS, June 5, 2007; 104(23): 9870 - 9875.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. Rusch, B. Musset, H. Wulf, A. Schuster, and D. E. Raines
Subunit-Dependent Modulation of the 5-Hydroxytryptamine Type 3 Receptor Open-Close Equilibrium by n-Alcohols
J. Pharmacol. Exp. Ther., June 1, 2007; 321(3): 1069 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. Ji and N. Suga
Serotonergic Modulation of Plasticity of the Auditory Cortex Elicited by Fear Conditioning
J. Neurosci., May 2, 2007; 27(18): 4910 - 4918.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
G. Manjarrez, R. Herrera, M. Leon, and J. Hernandez-R
A Low Brain Serotonergic Neurotransmission in Children With Type 1 Diabetes Detected Through the Intensity Dependence of Auditory-Evoked Potentials
Diabetes Care, January 1, 2006; 29(1): 73 - 77.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Z.-w. Zhang and D. Arsenault
Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex
J. Physiol., July 15, 2005; 566(2): 379 - 394.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. Stevens, D. Rusch, K. Solt, D. E. Raines, and P. A. Davies
Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols
J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 338 - 345.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Z. Xiang, L. Wang, and S. T. Kitai
Modulation of Spontaneous Firing in Rat Subthalamic Neurons by 5-HT Receptor Subtypes
J Neurophysiol, March 1, 2005; 93(3): 1145 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. V. Puig, F. Artigas, and P. Celada
Modulation of the Activity of Pyramidal Neurons in Rat Prefrontal Cortex by Raphe Stimulation In Vivo: Involvement of Serotonin and GABA
Cereb Cortex, January 1, 2005; 15(1): 1 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. V. Puig, N. Santana, P. Celada, G. Mengod, and F. Artigas
In Vivo Excitation of GABA Interneurons in the Medial Prefrontal Cortex through 5-HT3 Receptors
Cereb Cortex, December 1, 2004; 14(12): 1365 - 1375.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Santana, A. Bortolozzi, J. Serrats, G. Mengod, and F. Artigas
Expression of Serotonin1A and Serotonin2A Receptors in Pyramidal and GABAergic Neurons of the Rat Prefrontal Cortex
Cereb Cortex, October 1, 2004; 14(10): 1100 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Tan, P. Zhong, and Z. Yan
Corticotropin-Releasing Factor and Acute Stress Prolongs Serotonergic Regulation of GABA Transmission in Prefrontal Cortical Pyramidal Neurons
J. Neurosci., May 26, 2004; 24(21): 5000 - 5008.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-C. Beique, B. Campbell, P. Perring, M. W. Hamblin, P. Walker, L. Mladenovic, and R. Andrade
Serotonergic Regulation of Membrane Potential in Developing Rat Prefrontal Cortex: Coordinated Expression of 5-Hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 Receptors
J. Neurosci., May 19, 2004; 24(20): 4807 - 4817.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J.-C. Beique, E. M. Chapin-Penick, L. Mladenovic, and R. Andrade
Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex
J. Physiol., May 1, 2004; 556(3): 739 - 754.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Amargos-Bosch, A. Bortolozzi, M. V. Puig, J. Serrats, A. Adell, P. Celada, M. Toth, G. Mengod, and F. Artigas
Co-expression and In Vivo Interaction of Serotonin1A and Serotonin2A Receptors in Pyramidal Neurons of Prefrontal Cortex
Cereb Cortex, March 1, 2004; 14(3): 281 - 299.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. V. Puig, P. Celada, L. Diaz-Mataix, and F. Artigas
In Vivo Modulation of the Activity of Pyramidal Neurons in the Rat Medial Prefrontal Cortex by 5-HT2A Receptors: Relationship to Thalamocortical Afferents
Cereb Cortex, August 1, 2003; 13(8): 870 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan
Impaired Modulation of GABAergic Transmission by Muscarinic Receptors in a Mouse Transgenic Model of Alzheimer's Disease
J. Biol. Chem., July 11, 2003; 278(29): 26888 - 26896.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z.-w. Zhang
Serotonin Induces Tonic Firing in Layer V Pyramidal Neurons of Rat Prefrontal Cortex during Postnatal Development
J. Neurosci., April 15, 2003; 23(8): 3373 - 3384.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. A. van Hooft and W. J. Wadman
Ca2+ Ions Block and Permeate Serotonin 5-HT3 Receptor Channels in Rat Hippocampal Interneurons
J Neurophysiol, April 1, 2003; 89(4): 1864 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Z. Xiang and D. A. Prince
Heterogeneous Actions of Serotonin on Interneurons in Rat Visual Cortex
J Neurophysiol, March 1, 2003; 89(3): 1278 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-C. Norreel, J.-F. Pflieger, E. Pearlstein, J. Simeoni-Alias, F. Clarac, and L. Vinay
Reversible Disorganization of the Locomotor Pattern after Neonatal Spinal Cord Transection in the Rat
J. Neurosci., March 1, 2003; 23(5): 1924 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. C. Foehring, J. F. M. van Brederode, G. A. Kinney, and W. J. Spain
Serotonergic Modulation of Supragranular Neurons in Rat Sensorimotor Cortex
J. Neurosci., September 15, 2002; 22(18): 8238 - 8250.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Ferezou, B. Cauli, E. L. Hill, J. Rossier, E. Hamel, and B. Lambolez
5-HT3 Receptors Mediate Serotonergic Fast Synaptic Excitation of Neocortical Vasoactive Intestinal Peptide/Cholecystokinin Interneurons
J. Neurosci., September 1, 2002; 22(17): 7389 - 7397.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Mock, C. Schwarz, and P. Thier
Serotonergic Control of Cerebellar Mossy Fiber Activity by Modulation of Signal Transfer by Rat Pontine Nuclei Neurons
J Neurophysiol, August 1, 2002; 88(2): 549 - 564.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. V. Williams, S. G. Rao, and P. S. Goldman-Rakic
The Physiological Role of 5-HT2A Receptors in Working Memory
J. Neurosci., April 1, 2002; 22(7): 2843 - 2854.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Feng, X. Cai, J. Zhao, and Z. Yan
Serotonin Receptors Modulate GABAA Receptor Channels through Activation of Anchored Protein Kinase C in Prefrontal Cortical Neurons
J. Neurosci., September 1, 2001; 21(17): 6502 - 6511.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online