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The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 3006-3020
Copyright ©1999 by the American Physiological Society
1Section of Neurobiology, School of Medicine and 2Department of Computer Science, Yale University, New Haven, Connecticut 06510; and 3Department of Medical Physiology, Panum Institute, University of Copenhagen, Blegdamsvej, Copenhagen 2200, Denmark
Shen, Gongyu Y.,
Wei R. Chen,
Jens Midtgaard,
Gordon M. Shepherd, and
Michael L. Hines.
Computational Analysis of Action Potential Initiation in Mitral
Cell Soma and Dendrites Based on Dual Patch Recordings. J. Neurophysiol. 82: 3006-3020, 1999. In olfactory
mitral cells, dual patch recordings show that the site of action
potential initiation can shift between soma and distal primary dendrite
and that the shift is dependent on the location and strength of
electrode current injection. We have analyzed the mechanisms underlying
this shift, using a model of the mitral cell that takes advantage of
the constraints available from the two recording sites. Starting with
homogeneous Hodgkin-Huxley-like Na+-K+ channel
distribution in the soma-dendritic region and much higher sodium
channel density in the axonal region, the model's channel kinetics and
density were adjusted by a fitting algorithm so that the model response
was virtually identical to the experimental data. The combination of
loading effects and much higher sodium channel density in the axon
relative to the soma-dendritic region results in significantly lower
"voltage threshold" for action potential initiation in the axon;
the axon therefore fires first unless the voltage gradient in the
primary dendrite is steep enough for it to reach its higher threshold.
The results thus provide a quantitative explanation for the stimulus
strength and position dependence of the site of action potential
initiation in the mitral cell.
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