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The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 3359-3366
Copyright ©1999 by the American Physiological Society
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520
Zhang, Jun-Ming,
Xue-Jun Song, and
Robert
H. LaMotte.
Enhanced Excitability of Sensory Neurons in Rats With Cutaneous
Hyperalgesia Produced by Chronic Compression of the Dorsal Root
Ganglion. J. Neurophysiol. 82: 3359-3366, 1999. Pain and hyperalgesia can occur when the dorsal root
ganglion (DRG) and its roots are deformed mechanically in association with injuries or diseases of the spine. To evaluate the
electrophysiological changes that contribute to this sensory pathology,
intracellular recordings were obtained in vitro from DRGs that had
received a chronic mechanical compression [chronic compression of DRG
(CCD)]. The compression was produced by inserting L-shaped rods
ipsilaterally into the intervertebral foramina, one at L4
and the other at L5 in rats 1-14 days before the
recording. Control rats received a sham operation. Postoperatively, the
threshold force applied by punctate stimulation of the plantar surface
of the hind paw decreased significantly on the foot ipsilateral to the
CCD (mechanical hyperalgesia) but changed little on the contralateral
foot or on either foot for control rats. DRG somata were viewed through a microscope during recording and classified as small, medium, and
large according to their diameters. CCD cells in each size category
were more excitable than those of comparable size from control rats as
judged by the significantly lowered threshold currents and action
potential voltage thresholds. Spontaneous activity was recorded in 11%
of all the CCD cells tested. The spontaneous activity and/or changes in
both the threshold currents and action potential thresholds were
observed as early as one day after injury. The association of cutaneous
hyperalgesia with changes in the electrophysiological properties of DRG
cells suggests a possible role for intrinsic alterations in the
membrane properties of compressed DRG cells in the production and
persistence of chronic pain after certain spinal injuries or
pathologies of the spine.
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