JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 82: 3423-3433, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Qin, C.
Right arrow Articles by Foreman, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Qin, C.
Right arrow Articles by Foreman, R. D.

The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 3423-3433
Copyright ©1999 by the American Physiological Society

Chemical Activation of Cervical Cell Bodies: Effects on Responses to Colorectal Distension in Lumbosacral Spinal Cord of Rats

Chao Qin,1 Margaret J. Chandler,1 Kenneth E. Miller,2 and Robert D. Foreman1

 1Department of Physiology and  2Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190

Qin, Chao, Margaret J. Chandler, Kenneth E. Miller, and Robert D. Foreman. Chemical Activation of Cervical Cell Bodies: Effects on Responses to Colorectal Distension in Lumbosacral Spinal Cord of Rats. J. Neurophysiol. 82: 3423-3433, 1999. We have shown that stimulation of cardiopulmonary sympathetic afferent fibers activates relays in upper cervical segments to suppress activity of lumbosacral spinal cells. The purpose of this study was to determine if chemical excitation (glutamate) of upper cervical cell bodies changes the spontaneous activity and evoked responses of lumbosacral spinal cells to colorectal distension (CRD). Extracellular potentials were recorded in pentobarbital-anesthetized male rats. CRD (80 mmHg) was produced by inflating a balloon inserted in the descending colon and rectum. A total of 135 cells in the lumbosacral segments (L6-S2) were activated by CRD. Seventy-five percent (95/126) of tested cells received convergent somatic input from the scrotum, perianal region, hindlimb, and tail; 99/135 (73%) cells were excited or excited/inhibited by CRD; and 36 (27%) cells were inhibited or inhibited/excited by CRD. A glutamate (1 M) pledget placed on the surface of C1-C2 segments decreased spontaneous activity and excitatory CRD responses of 33/56 cells and increased spontaneous activity of 13/19 cells inhibited by CRD. Glutamate applied to C6-C7 segments decreased activity of 10/18 cells excited by CRD, and 9 of these also were inhibited by glutamate at C1-C2 segments. Glutamate at C6-C7 increased activity of 4/6 cells inhibited by CRD and excited by glutamate at C1-C2 segments. After transection at rostral C1 segment, glutamate at C1-C2 still reduced excitatory responses of 7/10 cells. Further, inhibitory effects of C6-C7 glutamate on excitatory responses to CRD still occurred after rostral C1 transection but were abolished after a rostral C6 transection in 4/4 cells. These data showed that C1-C2 cells activated with glutamate primarily produced inhibition of evoked responses to visceral stimulation of lumbosacral spinal cells. Inhibition resulting from activation of cells in C6-C7 segments required connections in the upper cervical segments. These results provide evidence that upper cervical cells integrate information that modulates activity of distant spinal neurons responding to visceral input.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Qin, R. D. Foreman, and J. P. Farber
Inhalation of a pulmonary irritant modulates activity of lumbosacral spinal neurons receiving colonic input in rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2052 - R2058.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Pan, M. R. Zahner, E. Kulikowicz, and L. P. Schramm
Effects of corticospinal tract stimulation on renal sympathetic nerve activity in rats with intact and chronically lesioned spinal cords
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R178 - R184.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Zhao, S. G. Waxman, and B. C. Hains
Extracellular Signal-Regulated Kinase-Regulated Microglia-Neuron Signaling by Prostaglandin E2 Contributes to Pain after Spinal Cord Injury
J. Neurosci., February 28, 2007; 27(9): 2357 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. C. Hains and S. G. Waxman
Activated microglia contribute to the maintenance of chronic pain after spinal cord injury.
J. Neurosci., April 19, 2006; 26(16): 4308 - 4317.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Wang, B. Tang, and R. J. Traub
Differential Processing of Noxious Colonic Input by Thoracolumbar and Lumbosacral Dorsal Horn Neurons in the Rat
J Neurophysiol, December 1, 2005; 94(6): 3788 - 3794.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Hua, T. Harrison, C. Qin, A. Reifsteck, B. Ricketts, C. Carnel, and C. A. Williams
c-Fos expression in rat brain stem and spinal cord in response to activation of cardiac ischemia-sensitive afferent neurons and electrostimulatory modulation
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2728 - H2738.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. S. Brink and P. Mason
Role for Raphe Magnus Neuronal Responses in the Behavioral Reactions to Colorectal Distension
J Neurophysiol, October 1, 2004; 92(4): 2302 - 2311.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Lu, C. Qin, R. D. Foreman, and J. P. Farber
Chemical activation of C1-C2 spinal neurons modulates intercostal and phrenic nerve activity in rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1069 - R1076.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Qin, B. G.-V. Meerveld, and R. D. Foreman
Visceromotor and Spinal Neuronal Responses to Colorectal Distension in Rats With Aldosterone Onto the Amygdala
J Neurophysiol, July 1, 2003; 90(1): 2 - 11.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. S. Brink and P. Mason
Raphe Magnus Neurons Respond to Noxious Colorectal Distension
J Neurophysiol, May 1, 2003; 89(5): 2506 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Qin, B. Greenwood-Van Meerveld, D. A. Myers, and R. D. Foreman
Corticosterone Acts Directly at the Amygdala to Alter Spinal Neuronal Activity in Response to Colorectal Distension
J Neurophysiol, March 1, 2003; 89(3): 1343 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Qin, J. P. Farber, M. J. Chandler, and R. D. Foreman
Chemical activation of C1-C2 spinal neurons modulates activity of thoracic respiratory interneurons in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R843 - R852.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. J. Chandler, J. Zhang, C. Qin, and R. D. Foreman
Spinal Inhibitory Effects of Cardiopulmonary Afferent Inputs in Monkeys: Neuronal Processing in High Cervical Segments
J Neurophysiol, March 1, 2002; 87(3): 1290 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Qin, M. J. Chandler, K. E. Miller, and R. D. Foreman
Responses and Afferent Pathways of Superficial and Deeper C1-C2 Spinal Cells to Intrapericardial Algogenic Chemicals in Rats
J Neurophysiol, April 1, 2001; 85(4): 1522 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Yuan, M. J. Chandler, R. D. Foreman, and J. P. Farber
Effects of abdominal or cardiopulmonary sympathetic afferents on upper cervical inspiratory neurons
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1289 - R1295.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online