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The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 3563-3574
Copyright ©1999 by the American Physiological Society
Section of Neurophysiology, Department of Physiology, The Panum Institute, 2200 Copenhagen N, Denmark
Tresch, Matthew C. and
Ole Kiehn.
Coding of Locomotor Phase in Populations of Neurons in Rostral
and Caudal Segments of the Neonatal Rat Lumbar Spinal Cord. J. Neurophysiol. 82: 3563-3574, 1999. Several
experiments have demonstrated that rostral segments of the vertebrate
lumbar spinal cord produce a rhythmic motor output more readily and of
better quality than caudal segments. Here we examine how this
rostrocaudal gradient of rhythmogenic capability is reflected in the
spike activity of neurons in the rostral (L2) and caudal
(L5) lumbar spinal cord of the neonatal rat. The spike
activity of interneurons in the ventromedial cord, a region necessary
for the production of locomotion, was recorded intracellularly with
patch electrodes and extracellularly with tetrodes during
pharmacologically induced locomotion. Both L2 and
L5 neurons tended to be active in phase with their
homologous ventral root. L5 neurons, however, had a wider
distribution of their preferred phases of activity throughout the
locomotor cycle than L2 neurons. The strength of modulation
of the activity of individual L2 neurons was also larger
than that of L5 neurons. These differences resulted in a
stronger rhythmic signal from the L2 neuronal population
than from the L5 population. These results demonstrate that
the rhythmogenic capability of each spinal segment was reflected in the
activity of interneurons located in the same segment. In addition to
paralleling the rostrocaudal gradient of rhythmogenic capability, these
results further suggest a colocalization of motoneurons and their
associated interneurons involved in the production of locomotion.
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