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The Journal of Neurophysiology Vol. 82 No. 6 December 1999, pp. 3580-3585
Copyright ©1999 by the American Physiological Society
RAPID COMMUNICATION
1Department of Integrative Medical Biology, Umeå University, S-901 87 Umeå, Sweden; 2Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585; and 3Department of Physiology, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo 181-8611, Japan
Alstermark, B.,
T. Isa,
Y. Ohki, and
Y. Saito.
Disynaptic Pyramidal Excitation in Forelimb Motoneurons Mediated
Via C3-C4 Propriospinal Neurons in the
Macaca fuscata. J. Neurophysiol. 82: 3580-3585, 1999. In contrast to findings in the
cat, it recently has been shown that disynaptic pyramidal EPSPs only
rarely are observed in forelimb motoneurons of the macaque monkey in
the intact spinal cord or after a corticospinal transection in
C5. This finding has been taken to indicate that the
disynaptic pyramidal excitatory pathway via
C3-C4 propriospinal neurons (PNs) is weakened
through phylogeny when the monosynaptic cortico-motoneuronal connection has been strengthened. We reinvestigate this issue with special focus
on the possibility that the inhibitory control of the
C3-C4 PNs may be stronger in the macaque
monkey than in the cat. The effect in forelimb motoneurons of
electrical stimulation in the contralateral pyramid was investigated in
anesthetized macaque monkeys (Macaca fuscata). We
confirmed the low frequency of disynaptic pyramidal EPSPs in forelimb
motoneurons. However, after intravenous injection of strychnine,
disynaptic EPSPs could be evoked in 39 of 41 forelimb motoneurons
recorded after lesion of the corticospinal fibers in C5. After a
corresponding lesion in C2, disynaptic pyramidal EPSPs were
observed in 2 of 25 motoneurons. In contrast to previous reports, we
conclude that C3-C4 PNs can mediate disynaptic
pyramidal excitation in high frequency of occurrence to forelimb
motoneurons in the C6-C8 segments and that
this transmission is under a stronger inhibitory control than in the
cat. Thus, the hypothesis that the disynaptic excitatory
cortico-motoneuronal pathway via the C3-C4 PNs
is weakened in parallel with the strengthened monosynaptic connection
through phylogeny is not supported by the present findings.
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