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The Journal of Neurophysiology Vol. 83 No. 1 January 2000, pp. 116-127
Copyright ©2000 by the American Physiological Society
1Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974; and 2The Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria 3078, Australia
Gelperin, A.,
J. Flores,
F. Raccuia-Behling, and
I.R.C. Cooke.
Nitric Oxide and Carbon Monoxide Modulate Oscillations of
Olfactory Interneurons in a Terrestrial Mollusk. J. Neurophysiol. 83: 116-127, 2000. Spontaneous or
odor-induced oscillations in local field potential are a general
feature of olfactory processing centers in a large number of vertebrate
and invertebrate species. The ubiquity of such oscillations in the
olfactory bulb of vertebrates and analogous structures in arthropods
and mollusks suggests that oscillations are fundamental to the
computations performed during processing of odor stimuli. Diffusible
intercellular messengers such as nitric oxide (NO) and carbon monoxide
(CO) also are associated with central olfactory structures in a wide
array of species. We use the procerebral (PC) lobe of the terrestrial
mollusk Limax maximus to demonstrate a role for NO and CO in
the oscillatory dynamics of the PC lobe: synthesizing enzymes for NO
and CO are associated with the PC lobes of Limax,
application of NO to the Limax PC lobe increases the
local field potential oscillation frequency, whereas block of NO
synthesis slows or stops the oscillation, the bursting cells of the PC
lobe that drive the field potential oscillation are driven to higher
burst frequency by application of NO, the nonbursting cells of the PC
lobe receive trains of inhibitory postsynaptic potentials, presumably
from bursting cells, due to application of NO, and application of CO to
the PC lobe by photolysis of caged CO results in an increase in
oscillation frequency proportional to CO dosage.
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