JN Journal of Neurophysiology
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J Neurophysiol 83: 1300-1306, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 83 No. 3 March 2000, pp. 1300-1306
Copyright ©2000 by the American Physiological Society

Exon 5 and Spermine Regulate Deactivation of NMDA Receptor Subtypes

Gavin Rumbaugh,1 Kate Prybylowski,1 Jian Feng Wang,2 and Stefano Vicini2

 1Department of Pharmacology and  2Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007

Rumbaugh, Gavin, Kate Prybylowski, Jian Feng Wang, and Stefano Vicini. Exon 5 and Spermine Regulate Deactivation of NMDA Receptor Subtypes. J. Neurophysiol. 83: 1300-1306, 2000. Deactivation of N-methyl-D-aspartate (NMDA) channels after brief agonist exposure determines the duration of their synaptic activation during excitatory neurotransmission. We performed patch-clamp recordings of L-glutamate responses from human embryonic kidney tumoral cells (HEK293) expressing NR1 subunit variants lacking exon 5 together with the NR2B subunit. These responses had deactivation components that lasted several seconds. The presence of exon 5 or spermine greatly accelerated deactivation of L-glutamate responses through alterations in desensitization. These effects were also observed at positive holding potentials and in the presence of physiological Mg2+. Thus NR1 splicing and polyamines may have profound effects on the kinetics of NMDA receptor-mediated synaptic transmission.




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