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The Journal of Neurophysiology Vol. 83 No. 4 April 2000, pp. 2012-2021
Copyright ©2000 by the American Physiological Society
1Johannes Müller Institute of Physiology (Charité), Humboldt University, D-10117 Berlin; and 2Max Delbrück Center for Molecular Medicine, D-13122 Berlin-Buch, Germany
Halbach, Oliver Von Bohlen Und,
Thomas Walther,
Michael Bader, and
Doris Albrecht.
Interaction Between Mas and the Angiotensin AT1
Receptor in the Amygdala. J. Neurophysiol. 83: 2012-2021, 2000. The Mas-protooncogene is a
maternally imprinted gene encoding an orphan G protein-coupled
receptor expressed mainly in limbic structures of the rodent CNS.
Because Mas and the product of the Mas-related gene enhance the effects of angiotensins on
cells expressing angiotensin receptors of the AT1 subtype, we first compared the distribution of cells expressing AT1 receptors in different limbic and thalamic brain structures in
Mas-knockout mice and in wildtype mice by an
immunohistochemical approach. No significant differences could be found
between the two strains. The Mas-protooncogene seems to
be implicated in the signal transduction of angiotensin receptors and
is expressed in the amygdala. Therefore we then analyzed whether field
potentials are altered by angiotensin II in brain slices of the
basolateral amygdala. An opposite action of angiotensin II was obtained
in mice lacking the Mas-protooncogene in comparison to
wildtype mice. The use of different angiotensin receptor antagonists
provides the first in vitro evidence for a functional interaction
between the Mas-protooncogene and the AT1 receptor.
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