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J Neurophysiol 83: 2163-2170, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 83 No. 4 April 2000, pp. 2163-2170
Copyright ©2000 by the American Physiological Society

Serotonin-Induced Spike Narrowing in a Locomotor Pattern Generator Permits Increases in Cycle Frequency During Accelerations

Richard A. Satterlie, Tigran P. Norekian, and Thomas J. Pirtle

Department of Biology, Arizona State University, Tempe, Arizona 85287-1501

Satterlie, Richard A., Tigran P. Norekian, and Thomas J. Pirtle. Serotonin-Induced Spike Narrowing in a Locomotor Pattern Generator Permits Increases in Cycle Frequency During Accelerations. J. Neurophysiol. 83: 2163-2170, 2000. During serotonin-induced swim acceleration in the pteropod mollusk Clione limacina, interneurons of the central pattern generator (CPG) exhibit significant action potential narrowing. Spike narrowing is apparently necessary for increases in cycle frequency during swim acceleration because, in the absence of narrowing, the combined duration of the spike and the inhibitory postsynaptic potential (IPSP) of a single cycle is greater than the available cycle duration. Spike narrowing could negatively influence synaptic efficacy in all interneuron connections, including reciprocal inhibitory connections between the two groups of antagonistic CPG interneurons as well as the interneuron-to-motoneuron connections. Thus compensatory mechanisms must exist to produce the overall excitatory behavioral change of swim acceleration. Such mechanisms include 1) a baseline depolarization of interneurons, which brings them closer to spike threshold, 2) enhancement of their postinhibitory rebound, and 3) direct modulation of swim motoneurons and muscles, all through inputs from serotonergic modulatory neurons.




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