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The Journal of Neurophysiology Vol. 83 No. 4 April 2000, pp. 2209-2216
Copyright ©2000 by the American Physiological Society
-, and 
-Opioid Receptor
Agonists on Mechanosensitive Gastric Vagal Afferent Fibers in the Rat
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242
Ozaki, Noriyuki,
J. N. Sengupta, and
G. F. Gebhart.
Differential Effects of µ-, -, and -Opioid Receptor
Agonists on Mechanosensitive Gastric Vagal Afferent Fibers in the Rat. J. Neurophysiol. 83: 2209-2216, 2000. Single-fiber recordings were made from the decentralized right cervical
vagus nerve (hyponodosal) of the rat. A total of 56 afferent fibers
that responded to gastric distension (GD) were studied: 6 fibers were
stimulated by phasic balloon GD, 50 by fluid GD. All fibers gave
increasing responses to increasing pressures of GD (5-60 mmHg). The
effects of µ-opioid (morphine), 
-opioid (SNC80), and 
-opioid
(EMD61,753, U62,066) receptor agonists were tested on responses of
afferent fibers to GD. Morphine, administered systemically over a broad
dose range (10 µg to 31 mg/kg, cumulative), had no effect on either
resting activity or responses of vagal afferent fibers to GD.
Similarly, the -opioid receptor agonist SNC80 (0.05-3.2 mg/kg) did
not affect resting activity or responses to GD. In contrast, cumulative
intra-arterial doses of the -opioid receptor agonist EMD61,753 or
U62,066 dose dependently attenuated afferent fiber responses to GD.
Doses producing inhibition to 50% of the control response to GD of
EMD61,753 (8.0 mg/kg) and U62,066 (8.8 mg/kg) did not differ. The
effect of U62,066 was moderately attenuated by a nonselective dose (4 mg/kg) of naloxone hydrochloride; the -opioid receptor-selective
antagonist nor-BNI (20 mg/kg) was ineffective. These results
demonstrate that -, but not µ- or -opioid receptor agonists
modulate visceral sensation conveyed by vagal afferent fibers
innervating the stomach. Given that -opioid receptor agonists
effects were only modestly antagonized by naloxone and not at all by
nor-BNI, the results point to a novel site of action.
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