JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 83: 2239-2259, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (66)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bester, H.
Right arrow Articles by Bernard, J.-F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bester, H.
Right arrow Articles by Bernard, J.-F.

The Journal of Neurophysiology Vol. 83 No. 4 April 2000, pp. 2239-2259
Copyright ©2000 by the American Physiological Society

Physiological Properties of the Lamina I Spinoparabrachial Neurons in the Rat

Hervé Bester, Victoria Chapman, Jean-Marie Besson, and Jean-François Bernard

Institut National de la Santé et de la Recherche Médicale U.161, École Pratique des Hautes Études, F-75014 Paris, France

Bester, Hervé, Victoria Chapman, Jean-Marie Besson, and Jean-François Bernard. Physiological Properties of the Lamina I Spinoparabrachial Neurons in the Rat. J. Neurophysiol. 83: 2239-2259, 2000. Single-unit extracellular recordings of spino-parabrachial (spino-PB) neurons (n = 53) antidromically driven from the contralateral parabrachial (PB) area were performed in the lumbar cord in anesthetized rats. All the spino-PB neurons were located in the lamina I of the dorsal horn. Their axons exhibited conduction velocities between 2.8 and 27.8 m/s, in the thin myelinated fibers range. They had an extremely low spontaneous activity (median = 0.064 Hz) and a small excitatory receptive field (<= 2 toes or pads). They were all activated by both peripheral A (mainly Adelta ) and C fibers after intense transcutaneous electrical stimulation. Their discharge always increased in response to noxious natural stimuli of increasing intensities. The great majority (75%) of spino-PB neurons were nociceptive specific, i.e., they were excited only by noxious stimuli. The remaining (25%) still were excited primarily by noxious stimuli but also responded moderately to innocuous stimuli. Almost all spino-PB neurons (92%, 49/53) were activated by both mechanical and heat noxious stimuli. Among them, 35% were in addition moderately activated by noxious cold (thresholds between +20 and -10°C). Only (8%, 4/53) responded exclusively to noxious heat. Spino-PB neurons clearly encoded the intensity of mechanical (n = 39) and thermal (n = 38) stimuli in the noxious range, and most of the individual stimulus-response functions were monotonic and positive up to 40/60 N · cm-2 and 50°C, respectively. For the mechanical modality, the mean threshold was 11.5 ± 1.25 N · cm-2 (mean ± SE), the response increased almost linearly with the logarithm of the pressure between 10 and 60 N · cm-2, the mean p50 (pressure evoking 50% of the maximum response) and the maximum responsiveness were: 30 ± 2.4 N · cm-2 and 40.5 ± 5 Hz, respectively. For the thermal modality, the mean threshold was 43.6 ± 0.5°C, the mean curve had a general sigmoid aspect, the steepest portion being in the 46-48°C interval, the mean t50 and the maximum responsiveness were: 47.4 ± 0.3°C and 40 ± 4.4 Hz, respectively. Most of the spino-PB neurons tested (13/16) had their noxiously evoked responses clearly inhibited by heterotopic noxious stimuli. The mean response to noxious stimuli during heterotopic stimuli was 31.7 ± 6.1% of the control response. We conclude that the nociceptive properties of the lamina I spino-PB neurons are reflected largely by those of PB neurons that were suggested to be involved in autonomic and emotional/aversive aspects of pain.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
B. K. Rycroft, K. S. Vikman, and M. J. Christie
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn
J. Physiol., May 1, 2007; 580(3): 883 - 894.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. L. Zanotto, A. W. Merrill, M. I. Carstens, and E. Carstens
Neurons in Superficial Trigeminal Subnucleus Caudalis Responsive to Oral Cooling, Menthol, and Other Irritant Stimuli
J Neurophysiol, February 1, 2007; 97(2): 966 - 978.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Zhang, S. Davidson, and G. J. Giesler Jr
Thermally identified subgroups of marginal zone neurons project to distinct regions of the ventral posterior lateral nucleus in rats.
J. Neurosci., May 10, 2006; 26(19): 5215 - 5223.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Torsney and A. B. MacDermott
Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord
J. Neurosci., February 8, 2006; 26(6): 1833 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Boscan, M. Dutschmann, H. Herbert, and J. F. R. Paton
Neurokininergic Mechanism within the Lateral Crescent Nucleus of the Parabrachial Complex Participates in the Heart-Rate Response to Nociception
J. Neurosci., February 9, 2005; 25(6): 1412 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. F. Finnegan, S.-R. Chen, and H.-L. Pan
Effect of the {micro} Opioid on Excitatory and Inhibitory Synaptic Inputs to Periaqueductal Gray-Projecting Neurons in the Amygdala
J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 441 - 448.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. Ruscheweyh, H. Ikeda, B. Heinke, and J. Sandkuhler
Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro
J. Physiol., March 1, 2004; 555(2): 527 - 543.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Gauriau and J.-F. Bernard
Posterior Triangular Thalamic Neurons Convey Nociceptive Messages to the Secondary Somatosensory and Insular Cortices in the Rat
J. Neurosci., January 21, 2004; 24(3): 752 - 761.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. Ikeda, B. Heinke, R. Ruscheweyh, and J. Sandkuhler
Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia
Science, February 21, 2003; 299(5610): 1237 - 1240.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
X.-P. Dong and T.-L. Xu
The Actions of Propofol on {gamma}-Aminobutyric Acid-A and Glycine Receptors in Acutely Dissociated Spinal Dorsal Horn Neurons of the Rat
Anesth. Analg., October 1, 2002; 95(4): 907 - 914.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. J. Todd, Z. Puskar, R. C. Spike, C. Hughes, C. Watt, and L. Forrest
Projection Neurons in Lamina I of Rat Spinal Cord with the Neurokinin 1 Receptor Are Selectively Innervated by Substance P-Containing Afferents and Respond to Noxious Stimulation
J. Neurosci., May 15, 2002; 22(10): 4103 - 4113.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Andrew and A. D. Craig
Responses of Spinothalamic Lamina I Neurons to Maintained Noxious Mechanical Stimulation in the Cat
J Neurophysiol, April 1, 2002; 87(4): 1889 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. D. Craig, K. Krout, and D. Andrew
Quantitative Response Characteristics of Thermoreceptive and Nociceptive Lamina I Spinothalamic Neurons in the Cat
J Neurophysiol, September 1, 2001; 86(3): 1459 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. G. Khasabov, D. M. Cain, D. Thong, P. W. Mantyh, and D. A. Simone
Enhanced Responses of Spinal Dorsal Horn Neurons to Heat and Cold Stimuli Following Mild Freeze Injury to the Skin
J Neurophysiol, August 1, 2001; 86(2): 986 - 996.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Bester, C. De Felipe, and S. P. Hunt
The NK1 Receptor Is Essential for the Full Expression of Noxious Inhibitory Controls in the Mouse
J. Neurosci., February 1, 2001; 21(3): 1039 - 1046.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online