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The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 2723-2739
Copyright ©2000 by the American Physiological Society
1Center for Neuroscience and 2Section of Neurobiology, Physiology and Behavior, University of California, Davis, California 95616
Recanzone, Gregg H.,
Darren C. Guard,
Mimi L. Phan, and
Tien-I K. Su.
Correlation Between the Activity of Single Auditory Cortical
Neurons and Sound-Localization Behavior in the Macaque Monkey. J. Neurophysiol. 83: 2723-2739, 2000. Lesion
studies have indicated that the auditory cortex is crucial for the
perception of acoustic space, yet it remains unclear how these neurons
participate in this perception. To investigate this, we studied the
responses of single neurons in the primary auditory cortex (AI) and the
caudomedial field (CM) of two monkeys while they performed a
sound-localization task. Regression analysis indicated that the
responses of ~80% of neurons in both cortical areas were
significantly correlated with the azimuth or elevation of the stimulus,
or both, which we term "spatially sensitive." The proportion of
spatially sensitive neurons was greater for stimulus azimuth compared
with stimulus elevation, and elevation sensitivity was primarily
restricted to neurons that were tested using stimuli that the monkeys
also could localize in elevation. Most neurons responded best to
contralateral speaker locations, but we also encountered neurons that
responded best to ipsilateral locations and neurons that had their
greatest responses restricted to a circumscribed region within the
central 60° of frontal space. Comparing the spatially sensitive
neurons with those that were not spatially sensitive indicated that
these two populations could not be distinguished based on either the
firing rate, the rate/level functions, or on their topographic location
within AI. Direct comparisons between the responses of individual
neurons and the behaviorally measured sound-localization ability
indicated that proportionally more neurons in CM had spatial
sensitivity that was consistent with the behavioral performance
compared with AI neurons. Pooling the responses across neurons
strengthened the relationship between the neuronal and psychophysical
data and indicated that the responses pooled across relatively few CM
neurons contain enough information to account for sound-localization
ability. These data support the hypothesis that auditory space is
processed in a serial manner from AI to CM in the primate cerebral cortex.
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