| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 2802-2813
Copyright ©2000 by the American Physiological Society
1Department of Psychology, The University of Connecticut, Storrs, Connecticut 06269; and 2Moscow Brain Research Institute, Russian Academy of Medical Sciences, Moscow 103064, Russia
Swadlow, Harvey A. and
Alexander G. Gusev.
The Influence of Single VB Thalamocortical Impulses on Barrel
Columns of Rabbit Somatosensory Cortex. J. Neurophysiol. 83: 2802-2813, 2000. Extracellular recordings were
obtained from single neurons in ventrobasal (VB) thalamus of awake
rabbits while field potentials were recorded at various depths within
topographically aligned and nonaligned barrel columns of somatosensory
cortex (S1). Spike-triggered averages of cortical field potentials were
obtained following action potentials in thalamic neurons. Action
potentials in a VB neuron elicited a cortical response within layer 4 with three distinct components. 1) A biphasic, initially
positive response (latency <1 ms) was interpreted to reflect
activation of the VB axon terminals (the AxTP). This response was not
affected by infusion of an
-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor antagonist within the barrel. In contrast, later components of
the response were completely eliminated and were interpreted to reflect
focal synaptic potentials. 2) A negative potential [focal synaptic negativity (FSN)] occurred at a mean latency of 1.65 ms and lasted ~4 ms. This response had a rapid rise time (~0.7 ms)
and was interpreted to reflect monosynaptic excitation. 3) The third component was a positive potential (the
FSP), with a slow rise time and a half-amplitude duration of ~30 ms.
The FSP showed a weak reversal in superficial cortical layers and was
interpreted to reflect di/polysynaptic inhibition. The amplitudes of
the AxTP, the FSN, and the FSP reached a peak near layer 4 and were
highly attenuated in both superficial and deep cortical layers. All
components were attenuated or absent when the cortical electrode was
missaligned from the thalamic electrode by a single cortical barrel.
Deconvolution procedures revealed that the autocorrelogram of the
presynaptic VB neuron had very little influence on either the amplitude
or duration of the AxTP or the FSN, and only a minor influence (mean,
11%) on the amplitude of the FSP. We conclude that individual VB
thalamic impulses entering a cortical barrel engage both monosynaptic
excitatory and di/polysynaptic inhibitory mechanisms. Putative
inhibitory interneurons of an S1 barrel receive a highly
divergent/convergent monosynaptic input from the topographically aligned VB barreloid, and this results in sharp synchrony among these
interneurons. We suggest that single-fiber access to disynaptic inhibition is facilitated by this sharp synchrony, and that the FSP
reflects a consequent synchronous wave of feed-forward inhibition within the S1 barrel.
This article has been cited by other articles:
|
|
 |
|
  C. Giaume, M. Maravall, E. Welker, and G. Bonvento The Barrel Cortex as a Model to Study Dynamic Neuroglial Interaction Neuroscientist, August 1, 2009; 15(4): 351 - 366. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Hull, J. S. Isaacson, and M. Scanziani Postsynaptic Mechanisms Govern the Differential Excitation of Cortical Neurons by Thalamic Inputs J. Neurosci., July 15, 2009; 29(28): 9127 - 9136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Heiss, Y. Katz, E. Ganmor, and I. Lampl Shift in the Balance between Excitation and Inhibition during Sensory Adaptation of S1 Neurons J. Neurosci., December 3, 2008; 28(49): 13320 - 13330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Fanselow, K. A. Richardson, and B. W. Connors Selective, State-Dependent Activation of Somatostatin-Expressing Inhibitory Interneurons in Mouse Neocortex J Neurophysiol, November 1, 2008; 100(5): 2640 - 2652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Stoelzel, Y. Bereshpolova, A. G. Gusev, and H. A. Swadlow The Impact of an LGNd Impulse on the Awake Visual Cortex: Synaptic Dynamics and the Sustained/Transient Distinction J. Neurosci., May 7, 2008; 28(19): 5018 - 5028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Simons, G. E. Carvell, H. T. Kyriazi, and R. M. Bruno Thalamocortical Conduction Times and Stimulus-Evoked Responses in the Rat Whisker-to-Barrel System J Neurophysiol, November 1, 2007; 98(5): 2842 - 2847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Khatri and D. J. Simons Angularly Nonspecific Response Suppression in Rat Barrel Cortex Cereb Cortex, March 1, 2007; 17(3): 599 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Melzer, R. N. S. Sachdev, N. Jenkinson, and F. F. Ebner Stimulus Frequency Processing in Awake Rat Barrel Cortex. J. Neurosci., November 22, 2006; 26(47): 12198 - 12205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Galvez, C. Weiss, A. P. Weible, and J. F. Disterhoft Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity. J. Neurosci., May 31, 2006; 26(22): 6062 - 6068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bereshpolova, C. R. Stoelzel, A. G. Gusev, T. Bezdudnaya, and H. A. Swadlow The impact of a corticotectal impulse on the awake superior colliculus. J. Neurosci., February 22, 2006; 26(8): 2250 - 2259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Higley and D. Contreras Balanced Excitation and Inhibition Determine Spike Timing during Frequency Adaptation J. Neurosci., January 11, 2006; 26(2): 448 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. S. Sachdev, F. F. Ebner, and C. J. Wilson Effect of Subthreshold Up and Down States on the Whisker-Evoked Response in Somatosensory Cortex J Neurophysiol, December 1, 2004; 92(6): 3511 - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wirth and H.-R. Luscher Spatiotemporal Evolution of Excitation and Inhibition in the Rat Barrel Cortex Investigated With Multielectrode Arrays J Neurophysiol, April 1, 2004; 91(4): 1635 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Bruno, V. Khatri, P. W. Land, and D. J. Simons Thalamocortical Angular Tuning Domains within Individual Barrels of Rat Somatosensory Cortex J. Neurosci., October 22, 2003; 23(29): 9565 - 9574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Blankenburg, B. Taskin, J. Ruben, M. Moosmann, P. Ritter, G. Curio, and A. Villringer Imperceptible Stimuli and Sensory Processing Impediment Science, March 21, 2003; 299(5614): 1864 - 1864. [Full Text] [PDF]
|
|
|
|
|
|
D. J. Pinto, J. A. Hartings, J. C. Brumberg, and D. J. Simons Cortical Damping: Analysis of Thalamocortical Response Transformations in Rodent Barrel Cortex Cereb Cortex, January 1, 2003; 13(1): 33 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hirsch Synaptic Physiology and Receptive Field Structure in the Early Visual Pathway of the Cat Cereb Cortex, January 1, 2003; 13(1): 63 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Linden and C. E. Schreiner Columnar Transformations in Auditory Cortex? A Comparison to Visual and Somatosensory Cortices Cereb Cortex, January 1, 2003; 13(1): 83 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Miller, M. A. Escabi, and C. E. Schreiner Feature Selectivity and Interneuronal Cooperation in the Thalamocortical System J. Neurosci., October 15, 2001; 21(20): 8136 - 8144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ahissar, R. Sosnik, K. Bagdasarian, and S. Haidarliu Temporal Frequency of Whisker Movement. II. Laminar Organization of Cortical Representations J Neurophysiol, July 1, 2001; 86(1): 354 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Porter, C. K. Johnson, and A. Agmon Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex J. Neurosci., April 15, 2001; 21(8): 2699 - 2710. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
