JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 83: 2854-2868, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (41)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Solomon, I. C.
Right arrow Articles by Neubauer, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solomon, I. C.
Right arrow Articles by Neubauer, J. A.

The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 2854-2868
Copyright ©2000 by the American Physiological Society

Pre-Bötzinger Complex Functions as a Central Hypoxia Chemosensor for Respiration In Vivo

Irene C. Solomon,1,2 Norman H. Edelman,1,2 and Judith A. Neubauer1

 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019; and  2Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794-8661

Solomon, Irene C., Norman H. Edelman, and Judith A. Neubauer. Pre-Bötzinger Complex Functions as a Central Hypoxia Chemosensor for Respiration In Vivo. J. Neurophysiol. 83: 2854-2868, 2000. Recently, we identified a region located in the pre-Bötzinger complex (pre-BötC; the proposed locus of respiratory rhythm generation) in which activation of ionotropic excitatory amino acid receptors using DL-homocysteic acid (DLH) elicits a variety of excitatory responses in the phrenic neurogram, ranging from tonic firing to a rapid series of high-amplitude, rapid rate of rise, short-duration inspiratory bursts that are indistinguishable from gasps produced by severe systemic hypoxia. Therefore we hypothesized that this unique region is chemosensitive to hypoxia. To test this hypothesis, we examined the response to unilateral microinjection of sodium cyanide (NaCN) into the pre-BötC in chloralose- or chloralose/urethan-anesthetized vagotomized, paralyzed, mechanically ventilated cats. In all experiments, sites in the pre-BötC were functionally identified using DLH (10 mM, 21 nl) as we have previously described. All sites were histologically confirmed to be in the pre-BötC after completion of the experiment. Unilateral microinjection of NaCN (1 mM, 21 nl) into the pre-BötC produced excitation of phrenic nerve discharge in 49 of the 81 sites examined. This augmentation of inspiratory output exhibited one of the following changes in cycle timing and/or pattern: 1) a series of high-amplitude, short-duration bursts in the phrenic neurogram (a discharge similar to a gasp), 2) a tonic excitation of phrenic neurogram output, 3) augmented bursts in the phrenic neurogram (i.e., eupneic breath ending with a gasplike burst), or 4) an increase in frequency of phrenic bursts accompanied by small increases or decreases in the amplitude of integrated phrenic nerve discharge. Our findings identify a locus in the brain stem in which focal hypoxia augments respiratory output. We propose that the respiratory rhythm generator in the pre-BötC has intrinsic hypoxic chemosensitivity that may play a role in hypoxia-induced gasping.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
B. J. Barnes, C.-M. Tuong, and N. M. Mellen
Functional Imaging Reveals Respiratory Network Activity During Hypoxic and Opioid Challenge in the Neonate Rat Tilted Sagittal Slab Preparation
J Neurophysiol, March 1, 2007; 97(3): 2283 - 2292.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. K. Purvis, J. C. Smith, H. Koizumi, and R. J. Butera
Intrinsic Bursters Increase the Robustness of Rhythm Generation in an Excitatory Network
J Neurophysiol, February 1, 2007; 97(2): 1515 - 1526.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Voituron, A. Frugiere, J. Champagnat, and L. Bodineau
Hypoxia-sensing properties of the newborn rat ventral medullary surface in vitro
J. Physiol., November 15, 2006; 577(1): 55 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. R. Noronha-de-Souza, K. C. Bicego, G. Michel, M. L. Glass, L. G. S. Branco, and L. H. Gargaglioni
Locus coeruleus is a central chemoreceptive site in toads
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R997 - R1006.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Kinkead, R. Gulemetova, and A. Bairam
Neonatal maternal separation enhances phrenic responses to hypoxia and carotid sinus nerve stimulation in the adult anesthetized rat
J Appl Physiol, July 1, 2005; 99(1): 189 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. J. Cummings and R. J. A. Wilson
Time-dependent modulation of carotid body afferent activity during and after intermittent hypoxia
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1571 - R1580.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Chen, K. H. Chon, and I. C. Solomon
Chemical activation of pre-Botzinger complex in vivo reduces respiratory network complexity
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1237 - R1247.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. C. Solomon
Glutamate Neurotransmission Is Not Required for, But May Modulate, Hypoxic Sensitivity of Pre-Botzinger Complex In Vivo
J Neurophysiol, March 1, 2005; 93(3): 1278 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
R. E. Winmill, A. K. Chen, and M. S. Hedrick
Development of the respiratory response to hypoxia in the isolated brainstem of the bullfrog Rana catesbeiana
J. Exp. Biol., January 15, 2005; 208(2): 213 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. E. Dick, Y.-H. Hsieh, S. Morrison, S. K. Coles, and N. Prabhakar
Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1121 - R1128.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. C. Solomon
Ionotropic excitatory amino acid receptors in pre-Botzinger complex play a modulatory role in hypoxia-induced gasping in vivo
J Appl Physiol, May 1, 2004; 96(5): 1643 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. Nsegbe, A. Wallen-Mackenzie, S. Dauger, J.-C. Roux, Y. Shvarev, H. Lagercrantz, T. Perlmann, and E. Herlenius
Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice
J. Physiol., April 1, 2004; 556(1): 43 - 59.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. S Cherniack
Oxygen sensing: applications in humans
J Appl Physiol, January 1, 2004; 96(1): 352 - 358.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Neubauer and J. Sunderram
Oxygen-sensing neurons in the central nervous system
J Appl Physiol, January 1, 2004; 96(1): 367 - 374.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. K. Mulkey, R. A. Henderson III, R. W. Putnam, and J. B. Dean
Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brain stem slices
J Appl Physiol, September 1, 2003; 95(3): 910 - 921.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. V. Forster
Plasticity in Respiratory Motor Control: Invited Review: Plasticity in the control of breathing following sensory denervation
J Appl Physiol, February 1, 2003; 94(2): 784 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. C. Solomon
Influence of respiratory network drive on phrenic motor output evoked by activation of cat pre-Botzinger complex
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R455 - R466.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Bavis and G. S. Mitchell
Plasticity in Respiratory Motor Control: Selected Contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
J Appl Physiol, January 1, 2003; 94(1): 399 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Mutolo, F. Bongianni, M. Carfi, and T. Pantaleo
Respiratory changes induced by kainic acid lesions in rostral ventral respiratory group of rabbits
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R227 - R242.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. M. Blitz and J.-M. Ramirez
Long-Term Modulation of Respiratory Network Activity Following Anoxia In Vitro
J Neurophysiol, June 1, 2002; 87(6): 2964 - 2971.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Q. Liu and M. T. T. Wong-Riley
Postnatal expression of neurotransmitters, receptors, and cytochrome oxidase in the rat pre-Botzinger complex
J Appl Physiol, March 1, 2002; 92(3): 923 - 934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. C. Solomon
Modulation of Gasp Frequency by Activation of Pre-Botzinger Complex In Vivo
J Neurophysiol, March 1, 2002; 87(3): 1664 - 1668.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Mazza, S. Thakkar-Varia, C. A. Tozzi, and J. A. Neubauer
Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla
J Appl Physiol, July 1, 2001; 91(1): 379 - 385.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online