JN AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 83: 3042-3048, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Handel, A.
Right arrow Articles by Glimcher, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Handel, A.
Right arrow Articles by Glimcher, P. W.

The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 3042-3048
Copyright ©2000 by the American Physiological Society

Contextual Modulation of Substantia Nigra Pars Reticulata Neurons

Ari Handel and Paul W. Glimcher

Center for Neural Science, New York University, New York, New York 10003

Handel, Ari and Paul W. Glimcher. Contextual Modulation of Substantia Nigra Pars Reticulata Neurons. J. Neurophysiol. 83: 3042-3048, 2000. Neurons in the substantia nigra pars reticulata (SNr) are known to encode saccadic eye movements within some, but not all, behavioral contexts. However, the precise contextual factors that effect the modulations of nigral activity are still uncertain. To further examine the effect of behavioral context on the SNr, we recorded the activity of 72 neurons while monkeys made saccades during a delayed saccade task and during periods of free viewing. We quantified and compared the movement fields of each neuron for saccades made under three different conditions: 1) spontaneous saccades, which shifted gaze during periods of free viewing when no stimuli were presented and no reinforcements were delivered; 2) fixational saccades, which brought gaze into alignment with a fixation target at the start of a delayed saccade trial, were necessary for trial completion, but were not directly followed by reinforcement; and 3) terminal saccades, which brought gaze into alignment with a visual target at the end of a delayed saccade trial and were directly followed by reinforcement. For three of the four SNr neuron classes, saccade-related modulations were only present before terminal saccades. For the fourth class, discrete pausers, saccade-related modulations were substantially larger for terminal saccades than for fixational saccades, and modulations were absent for spontaneous saccades. These results and other recent work on the basal ganglia suggest that some saccade-related signals in the SNr may be influenced by the reinforcement associated with a particular saccadic eye movement.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
M. Joshua, A. Adler, B. Rosin, E. Vaadia, and H. Bergman
Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons
J Neurophysiol, February 1, 2009; 101(2): 758 - 772.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Liu and M. A. Basso
Substantia Nigra Stimulation Influences Monkey Superior Colliculus Neuronal Activity Bilaterally
J Neurophysiol, August 1, 2008; 100(2): 1098 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Basso and P. Liu
Context-Dependent Effects of Substantia Nigra Stimulation on Eye Movements
J Neurophysiol, June 1, 2007; 97(6): 4129 - 4142.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Arkadir, G. Morris, E. Vaadia, and H. Bergman
Independent Coding of Movement Direction and Reward Prediction by Single Pallidal Neurons
J. Neurosci., November 10, 2004; 24(45): 10047 - 10056.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Condy, S. Rivaud-Pechoux, F. Ostendorf, C. J. Ploner, and B. Gaymard
Neural substrate of antisaccades: Role of subcortical structures
Neurology, November 9, 2004; 63(9): 1571 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Windels and E. A. Kiyatkin
GABA, Not Glutamate, Controls the Activity of Substantia Nigra Reticulata Neurons in Awake, Unrestrained Rats
J. Neurosci., July 28, 2004; 24(30): 6751 - 6754.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Salinas
Fast Remapping of Sensory Stimuli onto Motor Actions on the Basis of Contextual Modulation
J. Neurosci., February 4, 2004; 24(5): 1113 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Pare and D. P. Hanes
Controlled Movement Processing: Superior Colliculus Activity Associated with Countermanded Saccades
J. Neurosci., July 23, 2003; 23(16): 6480 - 6489.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
F. A. Middleton and P. L. Strick
Basal-ganglia 'Projections' to the Prefrontal Cortex of the Primate
Cereb Cortex, September 1, 2002; 12(9): 926 - 935.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Sato and O. Hikosaka
Role of Primate Substantia Nigra Pars Reticulata in Reward-Oriented Saccadic Eye Movement
J. Neurosci., March 15, 2002; 22(6): 2363 - 2373.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Basso and R. H. Wurtz
Neuronal Activity in Substantia Nigra Pars Reticulata during Target Selection
J. Neurosci., March 1, 2002; 22(5): 1883 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. J. Gdowski, L. E. Miller, T. Parrish, E. K. Nenonene, and J. C. Houk
Context Dependency in the Globus Pallidus Internal Segment During Targeted Arm Movements
J Neurophysiol, February 1, 2001; 85(2): 998 - 1004.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online