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The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 3133-3139
Copyright ©2000 by the American Physiological Society
RAPID COMMUNICATION
Departments of 1Psychiatry, 2Diagnostic Imaging and Therapeutics, 3Neurology, and 4Program in Functional NeuroImaging, University of Connecticut Health Center, Farmington, Connecticut 06030-2017
Clark, Vincent P.,
Sean Fannon,
Song Lai,
Randall Benson, and
Lance Bauer.
Responses to Rare Visual Target and Distractor Stimuli Using
Event-Related fMRI. J. Neurophysiol. 83: 3133-3139, 2000. Previous studies have found that the P300
or P3 event-related potential (ERP) component is useful in the
diagnosis and treatment of many disorders that influence CNS function.
However, the anatomic locations of brain regions involved in this
response are not precisely known. In the present event-related
functional magnetic resonance imaging (fMRI) study, methods of stimulus
presentation, data acquisition, and data analysis were optimized for
the detection of brain activity in response to stimuli presented in the
three-stimulus oddball task. This paradigm involves the interleaved,
pseudorandom presentation of single block-letter target and distractor
stimuli that previously were found to generate the P3b and P3a ERP
subcomponents, respectively, and frequent standard stimuli. Target
stimuli evoked fMRI signal increases in multiple brain regions
including the thalamus, the bilateral cerebellum, and the
occipital-temporal cortex as well as bilateral superior, medial,
inferior frontal, inferior parietal, superior temporal, precentral,
postcentral, cingulate, insular, left middle temporal, and right middle
frontal gyri. Distractor stimuli evoked an fMRI signal change
bilaterally in inferior anterior cingulate, medial frontal, inferior
frontal, and right superior frontal gyri, with additional activity in
bilateral inferior parietal lobules, lateral cerebellar hemispheres and
vermis, and left fusiform, middle occipital, and superior temporal
gyri. Significant variation in the amplitude and polarity of
distractor-evoked activity was observed across stimulus repetitions. No
overlap was observed between target- and distractor-evoked activity.
These event-related fMRI results shed light on the anatomy of responses
to target and distractor stimuli that have proven useful in many ERP
studies of healthy and clinically impaired populations.
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