JN Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 83: 3147-3153, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Belhaj-Saïf, A.
Right arrow Articles by Cheney, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Belhaj-Saïf, A.
Right arrow Articles by Cheney, P. D.

The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 3147-3153
Copyright ©2000 by the American Physiological Society

RAPID COMMUNICATION

Plasticity in the Distribution of the Red Nucleus Output to Forearm Muscles After Unilateral Lesions of the Pyramidal Tract

Abderraouf Belhaj-Saïf and Paul D. Cheney

Department of Molecular and Integrative Physiology and the Mental Retardation and Human Development Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160-7336

Belhaj-Saïf, Abderraouf and Paul D. Cheney. Plasticity in the Distribution of the Red Nucleus Output to Forearm Muscles After Unilateral Lesions of the Pyramidal Tract. J. Neurophysiol. 83: 3147-3153, 2000. It has been hypothesized that the magnocellular red nucleus (RNm) contributes to compensation for motor impairments associated with lesions of the pyramidal tract. To test this hypothesis, we used stimulus triggered averaging (StTA) of electromyographic (EMG) activity to characterize changes in motor output from the red nucleus after lesions of the pyramidal tract. Three monkeys were trained to perform a reach and prehension task. EMG activity was recorded from 11 forearm muscles including one elbow, five wrist, and five digit muscles. Microstimulation (20 µA at 20 Hz) was delivered throughout the movement task to compute StTAs. Two monkeys served as controls. In a third monkey, 65% of the left pyramidal tract had been destroyed by an electrolytic lesion method five years before recording. The results demonstrate a clear pattern of postlesion reorganization in red nucleus-mediated output effects on forearm muscles. The normally prominent extensor preference in excitatory output from the RNm (92% in extensors) was greatly diminished in the lesioned monkey (59%). Similarly, suppression effects, which are normally much more prominent in flexor than in extensor muscles (90% in flexors), were also more evenly distributed after recovery from pyramidal tract lesions. Because of the limited excitatory output from the RNm to flexor muscles that normally exists, loss of corticospinal output would leave control of flexors particularly weak. The changes in RNm organization reported in this study would help restore function to flexor muscles. These results support the hypothesis that the RNm is capable of reorganization that contributes to the recovery of forelimb motor function after pyramidal tract lesions.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
O. Chivatakarn, S. Kaneko, Z. He, M. Tessier-Lavigne, and R. J. Giger
The Nogo-66 Receptor NgR1 Is Required Only for the Acute Growth Cone-Collapsing But Not the Chronic Growth-Inhibitory Actions of Myelin Inhibitors
J. Neurosci., July 4, 2007; 27(27): 7117 - 7124.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X. Y. Chen, J. S. Carp, L. Chen, and J. R. Wolpaw
Sensorimotor Cortex Ablation Prevents H-Reflex Up-Conditioning and Causes a Paradoxical Response to Down-Conditioning in Rats
J Neurophysiol, July 1, 2006; 96(1): 119 - 127.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
G. Courtine, R. R. Roy, J. Raven, J. Hodgson, H. Mckay, H. Yang, H. Zhong, M. H. Tuszynski, and V. R. Edgerton
Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta)
Brain, October 1, 2005; 128(10): 2338 - 2358.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Lemon, S. Sasaki, K. Naito, K. Yoshimura, T. Isa, K. Seki, L.-G. Pettersson, B. Alstermark, and Y. Ohki
Cortico-motoneuronal system and dexterous finger movements
J Neurophysiol, December 1, 2004; 92(6): 3601 - 3603.
[Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
B. H. DOBKIN
Neurobiology of Rehabilitation
Ann. N.Y. Acad. Sci., December 1, 2004; 1038(1): 148 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Sasaki, T. Isa, L.-G. Pettersson, B. Alstermark, K. Naito, K. Yoshimura, K. Seki, and Y. Ohki
Dexterous Finger Movements in Primate Without Monosynaptic Corticomotoneuronal Excitation
J Neurophysiol, November 1, 2004; 92(5): 3142 - 3147.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. E. Lang and M. H. Schieber
Reduced Muscle Selectivity During Individuated Finger Movements in Humans After Damage to the Motor Cortex or Corticospinal Tract
J Neurophysiol, April 1, 2004; 91(4): 1722 - 1733.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. E. Lang and M. H. Schieber
Differential Impairment of Individuated Finger Movements in Humans After Damage to the Motor Cortex or the Corticospinal Tract
J Neurophysiol, August 1, 2003; 90(2): 1160 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. C. Zemke, P. J. Heagerty, C. Lee, and S. C. Cramer
Motor cortex organization after stroke is related to side of stroke and level of recovery.
Stroke, May 1, 2003; 34(5): e23 - e28.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online