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The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 3154-3159
Copyright ©2000 by the American Physiological Society
RAPID COMMUNICATION
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240
Florence, S. L.,
T. A. Hackett, and
F. Strata.
Thalamic and Cortical Contributions to Neural Plasticity
After Limb Amputation. J. Neurophysiol. 83: 3154-3159, 2000. Little is known about the substrates for the
large-scale shifts in the cortical representation produced by limb
amputation. Subcortical changes likely contribute to the cortical
remodeling, yet there is little data regarding the extent and pattern
of reorganization in thalamus after such a massive deafferentation.
Moreover, the relationship between changes in thalamus and in cortex
after injuries of this nature is virtually unexplored. Multiunit
microelectrode maps were made in the somatosensory thalamus and cortex
of two monkeys that had long-standing, accidental forelimb amputations. In the deprived portion of the ventroposterior nucleus of the thalamus
(VP), where stimulation to the hand would normally activate neurons,
new receptive fields had emerged. At some recording sites within the
deprived zone of VP, neurons responded to stimulation of the remaining
stump of the arm and at other sites neurons responded to stimulation of
both the stump and the face. This same overall pattern of
reorganization was present in the deprived hand representation of
cortical area 3b. Thus thalamic changes produced by limb amputation appear to be an important substrate of cortical reorganization. However, a decrease in the frequency of abnormal stump/face fields in
area 3b compared with VP and a reduction in the size of the fields
suggests that cortical mechanisms of plasticity may refine the
information relayed from thalamus.
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